T3969

I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.

Benzyl-PEG24-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands crucial for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Benzyl-PEG24-MS is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, with a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.

GluN2B receptor modulator-1 is a potent and selective allosteric negative modulator of the GluN2B subunit of NMDA receptors, exhibiting an IC50 value of 31 nM, enabling spcific modulation of subunit-specific allosteric control over the transmembrane ion channel pores of the NMDARs. providing a valuable tool in neuropharmacology and receptor-specific mechanisms relevant in the study of neurological diseases.

ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) that degrades the androgen receptor (AR), effectively reducing AR protein levels, suppressing AR-regulated gene expression in tumor tissues, and inhibiting tumor growth without evident toxicity. This compound holds promise for prostate cancer research.

Thalidomide-Piperazine 5-fluoride is a compound synthesized as an E3 ligase ligand-linker conjugate, incorporating a cereblon ligand derived from Thalidomide and utilizing a linker commonly employed in PROTAC technology.

Thalidomide-piperazine-Boc, an intermediate used in the synthesis of BCL6 PROTAC, targets the B-cell lymphoma 6 protein.

Thalidomide-O-C8-Boc is a Cereblon ligand derived from Thalidomide, primarily employed in the recruitment of CRBN protein. This ligand can be linked to a protein ligand via a linker to create PROTACs.