T21504

γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.

Bis (2-chloroethyl) phosphate (BCEP) is an organic phosphate ester (OPEs) linked to increased risks of early menopause and primary ovarian insufficiency (POI) according to studies. Additionally, BCEP exhibits nephrotoxic properties.

MANT-GppNHp is a competitive inhibitor of adenylyl cyclase (AC) and a fluorescently labeled GTP analog. It interacts with a hydrophobic pocket near the AC catalytic site through its MANT group, directly obstructing the binding of the substrate ATP. MANT-GppNHp can be utilized in studies of diseases such as cholera, which are associated with increased AC activity.

TTBK1-IN-3 (Compound 18) is a potent TTBK1 inhibitor, with a biochemical IC₅₀ of 18 nM and a cellular IC₅₀ of 259 nM. It is used in Alzheimer's disease research.

Antimetastatic agent-1 (Compound A-23) is a MET inhibitor. It effectively suppresses cancer metastasis.

Stibophen is a potent antiparasitic agent effective against Litomosoides carinii, Dipetalonema witei, and Brugia pahangi. It inhibits lactate accumulation and phosphofructokinase (PFK) activity in adult filarial worms. Additionally, Stibophen suppresses PFK activity in Ascaris and Hymenolepis diminuta, without affecting mammalian liver PFK. It is utilized in studies of schistosomiasis and filarial infections.

EP2 receptor agonist 2 (compound 18a) is a potent and selective G protein-biased EP2 receptor agonist with an efficacy of hEP2G protein EC50= 13 nM and hEP2βarrestin EC50 > 10000 nM. It shows exceptional selectivity over hEP1/3/4, hIP, and hFP, with EC50 values exceeding 10000 nM.

3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor with IC50 values of approximately 0.12 μM for hIRE1α-cyto and 6 μM for yeast Ire1. It suppresses XBP-1 splicing and induces apoptosis. This compound upregulates TXNIP mRNA expression levels while downregulating TXN expression. Furthermore, 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer and significantly inhibits the replication of the chikungunya virus.

Octadecyl β-D-glucopyranosiduronic acid (Compound 9) is an activator of parathyroid hormone 1 receptor (PTH1R) with a pEC50 value greater than 9. It can be utilized in research related to hypoparathyroidism.

Mono (2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP) is an oxidative metabolite of Di (2-ethylhexyl) phthalate (DEHP). Mono (2-ethyl-5-oxohexyl) phthalate may offer protection against sperm DNA damage. Di (2-ethylhexyl) phthalate is primarily used as a plasticizer in rigid polyvinyl chloride (PVC) to enhance flexibility, temperature resistance, optical clarity, strength, and kink resistance.

BI1071 is an orally active modulator of the Nur77-Bcl-2 apoptotic pathway. It binds to the Nur77-LBD protein with a Kd value of 0.17 μM. BI1071 activates the Nur77 signaling pathway and induces apoptosis by translocating to the mitochondria and interacting with Bcl-2. It inhibits tumor growth in SW620 xenograft mouse models and is applicable in colon cancer research.