T21153

Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.

MolPort-002-705-878 is a highly selective inhibitor of FMS-like tyrosine kinase 3 (FLT3), with a binding affinity of -11.33 kcal/mol. It effectively suppresses the proliferation of FLT3-mutant acute myeloid leukemia (AML) cells and holds potential for research into FLT3-mutant AML.

NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist with AC50 values of 1.681 μM and 0.989 μM for human and monkey, respectively. It is applicable in research on cardiovascular and other diseases.

Dalvotoclax (Example 8) is a selective inhibitor of BCL-2 that exhibits good liver microsomal stability. It effectively suppresses the activity of the anti-apoptotic proteins BCL-2 and BCL-XL and is applicable for research on B-cell leukemia.