T1870

Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.

SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.

DBA-DM4 is a drug-linker conjugate used in antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker [1].

SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1].

SPDH is a cleavable antibody-drug conjugate (ADC) linker utilized for the diagnosis and therapy of cancer as well as B cell proliferative diseases.

SPDMB is a glutathione-cleavable ADC linker used for antibody-drug conjugates (ADCs).

SPDMV-sulfo, a glutathione-cleavable ADC linker, facilitates the release of drugs from antibody-drug conjugates (ADCs).

SPDMV is a PEG-based ADC linker involved in the synthesis of antibody-coupled reactive molecules (ADCs).

SPDP-C6-Gly-Leu-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is used for the synthesis of antibody-drug conjugates (ADCs)[1].