T1660

Silybin A is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker and a PEG-based PROTAC linker, used to synthesize 6-OHDA-PEG3-yne, a compound containing 6-OHDA and Propargyl-PEG3-acid[1].

Propargyl-PEG2-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG2-N-bis(PEG2) is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs (proteolysis-targeting chimeras).

Propargyl-PEG2-NHBoc is a cleavable ADC linker used for creating antibody-drug conjugates (ADCs). Additionally, this PEG-based PROTAC linker is promising for synthesizing PROTACs[1].

Propargyl-PEG2-OH is a polyethylene glycol (PEG)-based PROTAC linker, specifically designed for efficient synthesis of Thalidomide-O-PEG2-propargyl.

Propargyl-PEG2-Tos is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective degradation of proteins by utilizing the ubiquitin-proteasome system within cells.

Propargyl-PEG3-alcohol is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Propargyl-PEG3-Boc, a PEG-based linker for PROTACs, connects two essential ligands vital for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Propargyl-PEG3-bromide is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose bromide group can undergo click chemistry (CuAAc) with alkyne-containing molecules.

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].