T1593

Ezetimibe (SCH 58235) is a dietary cholesterol absorption inhibitor that exerts its physiologic effect by decreasing cholesterol absorption.

m-PEG8-NHS ester is an 8-unit PEG-containing ADC linker that can be used to synthesize antibody-coupled reactive molecules (ADCs), which can be used to modify proteins and peptides.

m-PEG8-C10-phosphonic acid is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation via the ubiquitin-proteasome system within cells [PROTACs].

m-PEG8-(CH2)12-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based PROTAC linker, ideal for synthesizing PROTAC compounds[1].

m-PEG8-CH2CH2-NHS ester is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.

m-PEG8-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs.

m-PEG8-Mal is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.

m-PEG8-succinimidyl carbonate is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs) [1].

m-PEG8-thiol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Tos-PEG8-m, a PEG-based PROTAC linker, is a derivative of silybin ethers. It is utilized in the synthesis of Silymarin[1].

EBET-1593 is a BETPROTAC degrader that facilitates the ubiquitination and degradation of BET proteins. It serves as the primary payload and can be utilized in the synthesis of ADCs, such as 84-EBET, which exhibits antitumor activity against pancreatic ductal adenocarcinoma.

Ezetimibe-D4, a deuterium-labeled variant of Ezetimibe (T1593), functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2.

Ezetimibe-D4-1 is the deuterated form of Ezetimibe (T1593), which functions as a potent cholesterol absorption inhibitor and NPC1L1 inhibitor, and also exhibits Nrf2 activation properties.