T0945

Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Cyclosporin A-d4 (Major) is a deuterated compound of Cyclosporin A. Cyclosporin A has a CAS number of 59865-13-3. Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Cyclosporin A (Standard) is a reference standard for research and analysis in studies involving Cyclosporin A. Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4) is a 13C-labeled form of Cyclosporin A. Cyclosporin A is an immunosuppressant that binds to cyclophilin, inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 7 nM, and also suppresses the CD11a/CD18 adhesion molecules.

Cyclosporin A-d4 is a deuterated form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting calcineurin activity with an IC50 value of 7 nM. It also obstructs the adhesion molecules CD11a/CD18.

Cyclosporin A-d12 (Cyclosporine A-d12) is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. It also inhibits the adhesion molecule CD11a/CD18.