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Search Results for " sur1 "

Targets

13

Compounds

Cat No. Product Name Synonyms Targets
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T26324 VU0071063 VU 0071063,VU-0071063 Potassium Channel
VU0071063 is a Kir6.2/SUR1 activator.
T0816 Acetohexamide Acetohexamid,Dymelor,Gamadiabet Potassium Channel , NADPH
Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) wi...
T16110 ML418 Potassium Channel
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
T0371 Gliquidone AR-DF 26,Glurenorm Potassium Channel
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared...
T6587 Mitiglinide Calcium KAD-1229,S21403 ATPase , Potassium Channel
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
T1530 Mitiglinide calcium hydrate KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate Potassium Channel
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ...
T0127 Glimepiride Glimperide,HOE-490 Potassium Channel
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
T35635 Rac-trans-4-hydroxy Glyburide
rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide .1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.1rac-trans-4-hydroxy Glybu...
T17094 Tifenazoxide NN414 Others
Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.
T17240 VU041 Others
VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhi...
T21431 Mitiglinide
Mitiglinide (KAD-1229) is an insulinotropic agent that is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide ...
T60428 Cibenzoline
Cibenzoline is an antiarrhythmic agent that inhibits the KATP channel by directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline shows little anticholinergic activity. Cibenzoline mar...
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