pi4k — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61971	CHMFL-PI4K-127
	CHMFL-PI4K-127 (compound 15g) is a highly selective inhibitor of PfPI4K (Plasmodium falciparum PI4K kinase) with oral activity (IC50=0.9 nM). CHMFL-PI4K-127 shows strong inhibitory activity against Plasmodium falciparum ...
T16530	BF738735		Antiviral , PI4K
	BF738735 is a selective inhibitor of phosphatidylinositol 4-kinase III beta (PI4KIIIβ, IC50 = 5.7 nM) showing higher activity over α(IC50 = 1.7 μM). BF738735 exhibits a broad spectrum of antiviral activity.		Antiviral , PI4K
TQ0009	UCB9608		PI4K
	UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.		PI4K
T16125	MMV390048		Parasite , PI4K
	MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal...		Parasite , PI4K
T16967	T-00127_HEV1		PI4K
	T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta (IC50: 60 nM).		PI4K
T12454	PI-273		Apoptosis , PI4K
	PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells		Apoptosis , PI4K
T12468	PI4KIIIbeta-IN-10		PI3K , PI4K
	PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).		PI3K , PI4K
T2616	PIK-93	PIK 93	ATM/ATR , DNA-PK , Virus Protease , PI3K , Carbonic Anhydrase , PI4K , mTOR , HSV
	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T12469	PI4KIIIbeta-IN-9		PI3K , PI4K
	PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .		PI3K , PI4K
T5421	KDU691		Parasite , PI4K
	KDU691 is a PI4K inhibitor.		Parasite , PI4K
T4220	BQR-695	BQR695,NVP-BQR695	PI3K , Parasite , PI4K
	BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.		PI3K , Parasite , PI4K
T27499	GSK-A1		HCV Protease , PI4K
	GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.		HCV Protease , PI4K
T19840	GSK-F1	PI4KA inhibitor-F1	PI4K
	GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.		PI4K
T64106	PI4KIIIbeta-IN-11
	PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50=9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum.
T12467	PI4KIII beta inhibitor 3		PI3K
	PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).		PI3K
T13246	UCT943		Parasite , PI4K
	UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).		Parasite , PI4K
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T71694	BRD73842
	BRD73842 is an inhibitor of Plasmodium PI4K.
T25826	MMV024101	MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101
	MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent comp...
T79876	EDI048		PI4K
	EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].		PI4K
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits c...
T15651	KDU731		Others
	KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptospo...		Others