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Search Results for " myelofibrosis "

Targets

8

Compounds

4

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T9705 TL-895 BTK
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.
T3069 AZD-1480 JAK
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...
T2709 TAK-901 TAK901 JAK , CDK , Src , Aurora Kinase
TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.
T70823 Momelotinib HCl
Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
T11687 Itacitinib adipate Phosphatase
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelofibrosis.
T64283 Pacritinib hydrochloride
Pacritinib hydrochloride is a potent inhibitor of wild-type JAK2 (IC50: 23 nM) and the JAK2V617F mutant (IC50: 19 nM). Pacritinib hydrochloride can be used in the study of acute myeloid leukaemia (AML) and myelofibrosis ...
T9634 Bomedemstat
Bomedemstat (IMG-7289) is an orally active and irreversible inhibitor of the epigenetically active lysine-specific demethylase 1 (LSD1) in mouse models of myeloproliferative neoplasms (MPNs). Bomedemstat shows antineopla...
T70008 Bomedemstat ditosylate
Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05423 C-MPL Protein, Rat, Recombinant (hFc) Rat HEK293
CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number o...
TMPY-06797 C-MPL Protein, Human, Recombinant (His) Human HEK293
CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number o...
TMPY-06863 C-MPL Protein, Mouse, Recombinant (His) Mouse HEK293
CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number o...
TMPY-03421 C-MPL Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number o...
Cat No. Product Name
L9810 Anti-Fibrosis Compound Library

1180 compounds
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS;
TargetMol