3
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6057 | URMC-099 | ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy | |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). | |||
T6904 | Necrosulfonamide | (E)-Necrosulfonamide | MLK |
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec... | |||
T11520 | GW806742X | MLK , VEGFR | |
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. |