Exatecan Intermediate 1

Exatecan Intermediate 1 is a useful organic compound for research related to life sciences. The catalog number is T67020 and the CAS number is 110351-94-5.

(rac)-Exatecan Intermediate 1 is a camptothecin derivative, a potential topoisomerase I inhibitor, used in tumor research.

(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1. Known as compound 6, Exatecan Intermediate 1 serves as a precursor in the synthesis of Exatecan, a camptothecin-class anticancer agent. Exatecan acts by interfering with DNA to inhibit the proliferation and division of tumor cells, effectively suppressing tumor growth. It is primarily researched for its potential use in treating various cancers, including ovarian, lung, and breast cancer.

Exatecan Intermediate 1-d5 is the deuterated form of Exatecan Intermediate 1.

Exatecan (Intermediate 2), a derivative of GGFG-amide-glycol-amide-Exatecan, facilitates the synthesis of antibody-drug conjugates (ADCs) [1].

Benzyl 2-cyclopropyl-2-hydroxyacetate serves as an intermediate in the synthesis of an ADC linker. This linker, incorporating Benzyl 2-cyclopropyl-2-hydroxyacetate, can be conjugated with Exatecan and used in conjunction with antibodies (such as antibody hu2F7) [1].

Fmoc-Gly-NH-CH2-O-Cyclopropane-CH2COOH serves as an intermediate for ADC linker synthesis. This linker, which includes Benzyl 2-cyclopropyl-2-hydroxyacetate, is capable of being coupled to Exatecan and subsequently linked with antibodies (such as antibody hu2F7) [1].