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Search Results for " ezh1 "

18

Compounds

Cat No. Product Name Synonyms Targets
T1788 Tazemetostat E-7438,EPZ6438 Histone Methyltransferase
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epith...
T17002 Tazemetostat hydrobromide E-7438 hydrobromide,EPZ-6438 hydrobromide Histone Methyltransferase
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 n...
T3057 UNC1999 Histone Methyltransferase , Autophagy
UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).
T13279L Valemetostat DS-3201 Histone Methyltransferase
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor.
T6809 CPI-169 racemate CPI 169,CPI-169,CPI169 Epigenetic Reader Domain , Histone Methyltransferase
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T2435 EPZ011989 Histone Methyltransferase
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
T6059 GSK343 Histone Methyltransferase , Autophagy
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases.
T40199 Tulmimetostat CPI-0209 Histone Methyltransferase
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced solid tumors.
T1905 EPZ005687 Histone Methyltransferase
EPZ005687 is a potent and selective inhibitor of EZH2.
T6810 CPI-360 Synonym 2,CPI 360,CPI360 Apoptosis , Histone Methyltransferase
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
T23575 (R)-OR-S1 (R)ORS1,(R) OR S1,R-OR-S1
(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.
T13279 Valemetostat tosylate DS-3201 tosylate Histone Methyltransferase
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
T25400 EZH2-IN-3 EZH2 inhibitor 3,EZH2-inhibitor-3
EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
T73115 (S)-HH2853
(S)-HH2853, a pyridino-based compound featuring a five-membered aromatic ring, acts as a potent dual inhibitor of EZH1/2, displaying an IC50 of <100 nM specifically for the EZH2_Y641F mutation. This compound holds promis...
T73134 EZH2-IN-14
EZH2-IN-14 is a selective inhibitor of EZH2 (Histone Methyltransferase), demonstrating potent inhibition with an IC50 value of 12 nM. It specifically targets the methyltransferase activity of EZH2/PRC2, effectively reduc...
T27069 CPI-169 CPI 169 (R),CPI-169 (R)
CPI-169 (R) is a novel and potent inhibitor of EZH2.
T2435L EPZ011989 HCl(1598383-40-4 Free base) EPZ-011989 TFA,EPZ011989 TFA salt,EPZ 011989 TFA,EPZ011989 TFA
EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.
T15240 Tazemetostat trihydrochloride EPZ-6438 trihydrochloride,E-7438 trihydrochloride Histone Methyltransferase
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 an...
TargetMol