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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1788 | Tazemetostat | E-7438,EPZ6438 | Histone Methyltransferase |
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epith... | |||
T17002 | Tazemetostat hydrobromide | E-7438 hydrobromide,EPZ-6438 hydrobromide | Histone Methyltransferase |
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 n... | |||
T3057 | UNC1999 | Histone Methyltransferase , Autophagy | |
UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). | |||
T13279L | Valemetostat | DS-3201 | Histone Methyltransferase |
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor. | |||
T6809 | CPI-169 racemate | CPI 169,CPI-169,CPI169 | Epigenetic Reader Domain , Histone Methyltransferase |
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. | |||
T2435 | EPZ011989 | Histone Methyltransferase | |
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. | |||
T6059 | GSK343 | Histone Methyltransferase , Autophagy | |
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. | |||
T40199 | Tulmimetostat | CPI-0209 | Histone Methyltransferase |
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced solid tumors. | |||
T1905 | EPZ005687 | Histone Methyltransferase | |
EPZ005687 is a potent and selective inhibitor of EZH2. | |||
T6810 | CPI-360 | Synonym 2,CPI 360,CPI360 | Apoptosis , Histone Methyltransferase |
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. | |||
T23575 | (R)-OR-S1 | (R)ORS1,(R) OR S1,R-OR-S1 | |
(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2. | |||
T13279 | Valemetostat tosylate | DS-3201 tosylate | Histone Methyltransferase |
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma. | |||
T25400 | EZH2-IN-3 | EZH2 inhibitor 3,EZH2-inhibitor-3 | |
EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth. | |||
T73115 | (S)-HH2853 | ||
(S)-HH2853, a pyridino-based compound featuring a five-membered aromatic ring, acts as a potent dual inhibitor of EZH1/2, displaying an IC50 of <100 nM specifically for the EZH2_Y641F mutation. This compound holds promis... | |||
T73134 | EZH2-IN-14 | ||
EZH2-IN-14 is a selective inhibitor of EZH2 (Histone Methyltransferase), demonstrating potent inhibition with an IC50 value of 12 nM. It specifically targets the methyltransferase activity of EZH2/PRC2, effectively reduc... | |||
T27069 | CPI-169 | CPI 169 (R),CPI-169 (R) | |
CPI-169 (R) is a novel and potent inhibitor of EZH2. | |||
T2435L | EPZ011989 HCl(1598383-40-4 Free base) | EPZ-011989 TFA,EPZ011989 TFA salt,EPZ 011989 TFA,EPZ011989 TFA | |
EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM. | |||
T15240 | Tazemetostat trihydrochloride | EPZ-6438 trihydrochloride,E-7438 trihydrochloride | Histone Methyltransferase |
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 an... |