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Search Result

Search Results for " crm1 "

Targets

CRM1 CRM1

14

Compounds

1

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T79655 CRM1-IN-2 CRM1
CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibiting its nuclear export function. It demonstrates the capability to...
T79654 CRM1-IN-1 CRM1
CRM1-IN-1 (Compound KL1), a noncovalent inhibitor of CRM1, promotes nuclear degradation of CRM1 with an IC50 of 0.27 μM, inhibits CRM1-mediated nuclear export, suppresses cell proliferation, and induces apoptosis in colo...
T60416 CRM1 degrader 1
CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].
T24269 KPT-251 KPT251 Others
KPT-251 is a selective nuclear export inhibitor.
T15735 Leptomycin B CI 940,LMB CRM1 , Antibiotic , Antifungal
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a ...
T2425 KPT185 KPT-185,KPT 185 CRM1
KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
T6074 KPT276 KPT-276,KPT 276 CRM1
KPT276 (KPT 276) is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1.
T14885 CBS9106 SL-801 CRM1
CBS9106 (SL-801) is a reversible oral inhibitor of CRM1 with CRM1 degrading and antitumor activities. CBS9106 arrests the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of can...
T6123 Verdinexor KPT-335 CRM1
Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.
T1844 KPT330,(E)- (E)-RN,KPT-330,KPT330,KPT 330 Others , CRM1
(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.
T6106 Selinexor (KPT-330) Selinexor,KPT-330 CRM1
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.
T16548 PKF050-638 HIV Protease
PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC50=0.04 μM).
T81936 LFS-1107 CRM1
LFS-1107, a reversible CRM1 inhibitor (Kd: 12.5 pM), selectively targets and eliminates ENKTL cells, offering potential for cancer research applications [1].
T11766 Eltanexor Z-isomer KPT-8602 (Z-isomer) Others
Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a...
Cat No. Product Name Synonyms Targets
T11837 Leptomycin A CRM1
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the...

Natural Products

Leptomycin A
T11837
Synonym:
Target: CRM1

Recombinant Proteins

Species：
HMPV (2)
Human (2)
Expression System：
E. coli (2)
HEK293 (1)
Yeast (1)
Tag：
C-6His (1)
His (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01673 Human metapneumovirus (strain CAN97-83) Matrix protein (His) HMPV Yeast
Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the acti...
TMPH-01672 Human metapneumovirus (strain CAN97-83) Matrix protein (His & Myc) HMPV E. coli
Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the acti...
TMPJ-01297 WIBG Protein, Human, Recombinant (His) Human E. coli
Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for ...
TMPY-02198 ILKAP Protein, Human, Recombinant (His) Human HEK293
Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...
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