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Search Results for " cl-55 "

1

Compounds

28

Recombinant Proteins

Cat No. Product Name
T23893 CL-55
CL-55 is a novel inhibitor of T3SS.
Cat No. Product Name Species Source
TMPY-00855 IL-25/IL17E Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–produ...
TMPY-04793 IL-35 Protein, Human, Recombinant (Flag & His) Human HEK293
IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and T...
TMPY-00653 C5 Protein, Human, Recombinant (C5a) Human E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity...
TMPY-05057 C5 Protein, Human, Recombinant (His & FLAG) Human HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity...
TMPK-01268 Complement Component C2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
TMPY-06531 IL-15 & IL-15RA Protein, Mouse, Recombinant (His) Mouse HEK293
IL-15 and IL-15 receptor alpha (IL-15Rα) play a significant role in multiple aspects of T cell biology. Interleukin (IL)-15 is essential for natural killer (NK), NKT and memory (m) CD8+ T cell development and function, and is currently under investigation as an immunotherapeutic agent for the treatment of cancer. Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL-15 Rα) in solution, inspired by the natural trans-presentation of IL-15, advanc...
TMPY-03879 IL-35 Protein, Human, Recombinant Human HEK293
IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and T...
TMPY-04632 IL-15 Protein, Human, Recombinant Human E. coli
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ...
TMPY-03607 Cofilin Protein, Human, Recombinant (His) Human E. coli
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a...
TMPJ-01462 IL-15RA&IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc) Human Human Cells
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ...
TMPY-02176 Harmonin/USH1C Protein, Human, Recombinant (His) Human E. coli
Harmonin, also known as Antigen NY-CO-38 / NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein and USH1C, is a protein that is expressed in small intestine, colon, kidney, eye and weakly in pancreas. USH1C is expressed also in vestibule of the inner ear. USH1C contains 3 PDZ (DHR) domains. USH1C may be involved in protein-protein interaction. Defects in USH1C are the cause of Usher syndrome type 1C (USH1C), als...
TMPY-00843 IL-25/IL17E Protein, Human, Recombinant (hFc) Human HEK293
Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–produ...
TMPY-00693 Carbonic Anhydrase X Protein, Human, Recombinant Human HEK293
Carbonic anhydrase X, also called carbonic anhydrase - related protein X (CARPX) and CA1, belongs to the CA family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide in various biological processes such as respiration, renal tubular acidification and bone resorption. The secreted protein CARPX without CA activity (hydration of CO2) is identified as an acatalytic member of the alpha-carbonic anhydrase subgroup. CARP X expression is detected in the adult total brain a...
TMPY-01351 Carbonic Anhydrase X Protein, Human, Recombinant (His) Human HEK293
Carbonic anhydrase X, also called carbonic anhydrase - related protein X (CARPX) and CA1, belongs to the CA family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide in various biological processes such as respiration, renal tubular acidification and bone resorption. The secreted protein CARPX without CA activity (hydration of CO2) is identified as an acatalytic member of the alpha-carbonic anhydrase subgroup. CARP X expression is detected in the adult total brain a...
TMPY-06814 C5 Protein, Human, Recombinant (Flag) Human HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity...
TMPK-00702 ANTXR2 Protein, Human, Recombinant (His) Human HEK293
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
TMPY-00615 ANTXR2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS ide...
TMPY-04094 ANTXR2 Protein, Mouse, Recombinant (His) Mouse HEK293
Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS ide...
TMPY-01749 Ephrin A5 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage...
TMPY-01748 Ephrin A5 Protein, Mouse, Recombinant (His) Mouse HEK293
Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage...

Recombinant Proteins

IL-25/IL17E Protein, Mouse, Recombinant (His)
TMPY-00855
Species: Mouse
Source: HEK293
IL-35 Protein, Human, Recombinant (Flag & His)
TMPY-04793
Species: Human
Source: HEK293
C5 Protein, Human, Recombinant (C5a)
TMPY-00653
Species: Human
Source: E. coli
C5 Protein, Human, Recombinant (His & FLAG)
TMPY-05057
Species: Human
Source: HEK293
Complement Component C2 Protein, Cynomolgus, Recombinant (His)
TMPK-01268
Species: Cynomolgus
Source: HEK293
IL-15 & IL-15RA Protein, Mouse, Recombinant (His)
TMPY-06531
Species: Mouse
Source: HEK293
IL-35 Protein, Human, Recombinant
TMPY-03879
Species: Human
Source: HEK293
IL-15 Protein, Human, Recombinant
TMPY-04632
Species: Human
Source: E. coli
Cofilin Protein, Human, Recombinant (His)
TMPY-03607
Species: Human
Source: E. coli
IL-15RA&IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
TMPJ-01462
Species: Human
Source: Human Cells
Harmonin/USH1C Protein, Human, Recombinant (His)
TMPY-02176
Species: Human
Source: E. coli
IL-25/IL17E Protein, Human, Recombinant (hFc)
TMPY-00843
Species: Human
Source: HEK293
Carbonic Anhydrase X Protein, Human, Recombinant
TMPY-00693
Species: Human
Source: HEK293
Carbonic Anhydrase X Protein, Human, Recombinant (His)
TMPY-01351
Species: Human
Source: HEK293
C5 Protein, Human, Recombinant (Flag)
TMPY-06814
Species: Human
Source: HEK293
ANTXR2 Protein, Human, Recombinant (His)
TMPK-00702
Species: Human
Source: HEK293
ANTXR2 Protein, Mouse, Recombinant (hFc)
TMPY-00615
Species: Mouse
Source: HEK293
ANTXR2 Protein, Mouse, Recombinant (His)
TMPY-04094
Species: Mouse
Source: HEK293
Ephrin A5 Protein, Mouse, Recombinant (hFc)
TMPY-01749
Species: Mouse
Source: HEK293
Ephrin A5 Protein, Mouse, Recombinant (His)
TMPY-01748
Species: Mouse
Source: HEK293
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TargetMol