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By Target- AChR
- Aminopeptidase(1)
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Results for "
CHR-2797
" in TargetMol Product Catalog- Inhibitors & Agonists1
Tosedostat
CHR-2797
T6301238750-77-1
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Intracellularly converted into the poorly membrane-permeable active metabolite (CHR-79888), it inhibits puromycin-sensitive aminopeptidase (PuSA) and leukotriene A4 (LTA4) hydrolase. This inhibition in tumor cells may lead to amino acid deprivation, suppressed protein synthesis, increased proapoptotic protein Noxa levels, and ultimately, cell death.
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