Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc

Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker, used for synthesizing PROTACs[1].

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2].

C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl/ether-based PROTAC linker for synthesizing PROTACs[1].

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based linker, suitable for PROTAC synthesis [1].

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound utilized in the synthesis of PROTAC MG-277[1].

Azido-PEG3-C-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker employed in PROTAC synthesis[1].

Bromoacetamido-PEG9-ethylcarbamoyl-C8-Boc represents a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

N-Boc-cis-4-hydroxy-D-proline methyl ester is a useful organic compound for research related to life sciences. The catalog number is T66907 and the CAS number is 114676-69-6.

4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-derived PROTAC linker, suitable for the synthesis of PROTACs.

Azido-PEG8-C-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker enabling the synthesis of PROTACs [1].

9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

N-Boc-cis-4-hydroxy-L-proline is a useful organic compound for research related to life sciences. The catalog number is T66248 and the CAS number is 87691-27-8.

Boc-NH-PEG-amine (MW 3400) serves as a PEG-based PROTAC linker and finds application in PROTAC synthesis[1].

Bromoacetamido-C2-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker with a bromoacetamido functional group and a tert-butoxycarbonyl (Boc) protecting group. It serves as an integral component in the synthesis of proteolysis-targeting chimeras (PROTACs), which are innovative compounds used for targeted protein degradation[1].

Boc-NH-PEG-amine (MW 2000) is a polyethylene glycol (PEG)-based linker for PROTAC synthesis[1].

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bromoacetamido-PEG8-Boc is a PEG-based linker compound utilized for synthesizing PROTACs, which are molecules designed for targeted protein degradation[1].

N-Boc-cis-4-Hydroxy-D-proline is a useful organic compound for research related to life sciences. The catalog number is T65722 and the CAS number is 135042-12-5.

Bromoacetamido-PEG9-ethylcarbamoyl-C12-Boc is a polyethylene glycol (PEG) derived linker employed for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a polyethylene glycol (PEG)-derived PROTAC linker, which finds application in the synthesis of PROTACs[1].

Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Bromoacetamido-PEG3-C2-Boc is a polyethylene glycol (PEG) derived linker that is suitable for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Bromoacetamido-PEG4-C2-Boc is a polyethylene glycol (PEG)- and alkyl/ether-based linker commonly employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].