Bis-PEG1-acid

Bis-PEG1-acid is a PEG-based linker for PROTACs [PROteolysis TArgeting Chimeras] that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

Acid-PEG1-bis-PEG3-BCN, a cleavable 4-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

Bis-PEG1-sulfonic acid is a homo-bifunctional PEG derivative that can be utilized for drug delivery.

Boc-NH-Bis(acid-PEG1-m) is a PEG derivative that includes a carboxylic acid moiety. It is capable of reacting with amine-containing molecules.