BChE-IN-12

BChE-IN-12, also known as compound 12, is a potent non-competitive inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 2.3 μM. Derived from Bletilla striata, it is utilised in research related to Alzheimer's disease (AD) [1].

AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.

BChE-IN-41 is a highly selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 12 nM and a Ki of 6.6 nM. It exhibits significant brain permeability, with a brain-to-plasma ratio of 9.0. BChE-IN-41 enhances cognitive function in mice with scopolamine and Aβ1-42-induced symptoms of Alzheimer's disease.

BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE with a Ki value of 0.182 μM, and it exhibits significant chelating abilities towards Zn 2+. These characteristics make BChE-IN-6 a valuable tool for researchers in the field of Alzheimer's disease (AD) [1].