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Search Results for " ascr#2 "

3

Compounds

293

Recombinant Proteins

Cat No. Product Name
T13555 Ascr#2 Ascaroside C6 Others
Ascr#2, an ascaroside identified in Caenorhabditis elegans, demonstrates potent dauer formation promotion. Additionally,...
T13558 Ascr#8 Others
Ascr#8 is a dauer-inducing ascaroside isolated from Caenorhabditis elegans. It synergizes with ascr#2 and ascr#3, and st...
T13556 Ascr#3 Others
Ascr#3, an ascaroside isolated from Caenorhabditis elegans, acts as a potent male attractant, and also promotes dauer fo...
Cat No. Product Name Species Source
TMPY-02011 CD96 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-00748 Nectin-2 Protein, Human, Recombinant Human HEK293
Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can in...
TMPY-00850 ST2/IL-1 RL1 Protein, Human, Recombinant Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in fa...
TMPY-00341 FGFR3 Protein, Human, Recombinant (alpha IIIb, His) Human HEK293
FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalitie...
TMPY-04116 Human KRAS / K-Ras (G12C, Q61H) Protein (His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Once it is turned on it recruits and activates proteins necessary for the propagation of growth factor and other receptors' signal, such as c-Raf and PI 3-kinase. It binds ...
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His) Human HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's dise...
TMPY-00849 ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in fa...
TMPY-00871 LAYN Protein, Human, Recombinant (hFc) Human HEK293
Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, a ten-amino acid motif in the Layilin cytoplasmic domain is suffic...
TMPY-02358 CD98 Protein, Mouse, Recombinant (His) Mouse HEK293
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester s...
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) Human HEK293
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific ...
TMPY-04356 GSK3B Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, brain, and kidney. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in the GSK3B gene have been implicated in modifying the risk of Parkinson's disease, and studies in mice show that overexpression of this gene may be re...
TMPY-01359 ST2/IL-1 RL1 Protein, Human, Recombinant (His) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in fa...
TMPY-01199 CD74 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-05586 CD28H/TMIGD2 Protein, Human, Recombinant (His & AVI), Biotinylated Human HEK293
The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent in mouse and rat genomes. The immunoglobulin domain of IGPR-1 was predicted to be Ig V (variable) fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-04844 BTN3A1 Protein, Human, Recombinant (His) Human HEK293
BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmembrane domain, and a large carboxyl-terminal domain termed B3.2 (or PRYSPRY) located in the cell cytoplasm. There are three human BTN3A loci, BTN3A1, BTN3A2, and BTN3A3, and clear orthologs of BTN3A molecules, now called CD277, are absent from the mouse genome. Despite its similari...
TMPY-01985 CD32B/Fcgr2b Protein, Human, Recombinant (His & AVI), Biotinylated Human HEK293
TMPY-00751 TrkB Protein, Human, Recombinant (His) Human HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-04113 Human KRAS / K-Ras (G12D & Q61H) Protein (His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Once it is turned on it recruits and activates proteins necessary for the propagation of growth factor and other receptors' signal, such as c-Raf and PI 3-kinase. It binds ...
TMPJ-00850 ST2 Protein, Mouse, Recombinant (His) Mouse Human Cells
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen act...

Recombinant Proteins

CD96 Protein, Human, Recombinant (His)
TMPY-02011
Species: Human
Source: HEK293
Nectin-2 Protein, Human, Recombinant
TMPY-00748
Species: Human
Source: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant
TMPY-00850
Species: Human
Source: HEK293
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
TMPY-00341
Species: Human
Source: HEK293
Human KRAS / K-Ras (G12C, Q61H) Protein (His)
TMPY-04116
Species: Human
Source: E. coli
Clusterin Protein, Human, Recombinant (CLU34, His)
TMPY-01691
Species: Human
Source: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
TMPY-00849
Species: Human
Source: HEK293
LAYN Protein, Human, Recombinant (hFc)
TMPY-00871
Species: Human
Source: HEK293
CD98 Protein, Mouse, Recombinant (His)
TMPY-02358
Species: Mouse
Source: HEK293
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
TMPY-00891
Species: Human
Source: HEK293
GSK3B Protein, Human, Recombinant (His)
TMPY-04356
Species: Human
Source: Baculovirus-Insect Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
TMPY-01359
Species: Human
Source: HEK293
CD74 Protein, Human, Recombinant (His)
TMPY-01199
Species: Human
Source: HEK293
CD28H/TMIGD2 Protein, Human, Recombinant (His & AVI), Biotinylated
TMPY-05586
Species: Human
Source: HEK293
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Source: Baculovirus-Insect Cells
BTN3A1 Protein, Human, Recombinant (His)
TMPY-04844
Species: Human
Source: HEK293
CD32B/Fcgr2b Protein, Human, Recombinant (His & AVI), Biotinylated
TMPY-01985
Species: Human
Source: HEK293
TrkB Protein, Human, Recombinant (His)
TMPY-00751
Species: Human
Source: HEK293
Human KRAS / K-Ras (G12D & Q61H) Protein (His)
TMPY-04113
Species: Human
Source: E. coli
ST2 Protein, Mouse, Recombinant (His)
TMPJ-00850
Species: Mouse
Source: Human Cells
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TargetMol