8 iso prostaglandin e1

8-iso Prostaglandin E1 causes spasm in the pulmonary veins of dogs and also acts as a vasodilator.

Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.

Prostaglandin E1-d4 is the deuterated form of Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostaglandin receptor ligand with Ki values of 1.1 nM, 2.1 nM, 10 nM, 33 nM, and 36 nM for mouse EP3, EP4, EP2, IP, and EP1, respectively. It induces vasodilation and inhibits platelet aggregation, and serves as a vasodilator in research on peripheral vascular diseases.