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By Target- NOD-like Receptor (NLR)
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Results for "
5418-95-1
" in TargetMol Product Catalog- Inhibitors & Agonists1
2-Guanidinobezimidazole
2GBI
T2067715418-95-1
2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).
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