3-cyano-7-hydroxycoumarin

3-Cyano-7-hydroxycoumarin (3-Cyanoumbelliferone) is a macrophage inhibitor of macrophage inhibitory factor (MIF) interconjugate isomerase with a Ki of 2.9 μM. 3-Cyano-7-hydroxycoumarin belongs to the group of coumarin derivatives, which can be used as molecular probes and fluorescent dyes.

7-Hydroxycoumarin-3-carboxylic acid (7-HC-3-CA) is a safe anti-browning agent that inhibits tyrosinase activity, used in food preservation and human pigmentation research.

3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .

FHZ is a fluorescent probe (IUPAC: 2-(7-hydroxy-3H-phenoxazin-3-one-10-yl)benzoic acid), widely utilized in biological imaging due to its high sensitivity and selectivity in detecting specific molecular targets within cellular environments, exhibiting optimal excitation and emission spectra for various fluorescence microscopy applications.

8-(4-ethynylphenyl)-1,3,5,7-tetramethyl BODIPY is an organic fluorescent dye characterized by an ethynylphenyl group at the 8-position of the boron dipyrromethene (BODIPY) structure and methyl substituents at the 1, 3, 5, and 7 positions. It boasts a high fluorescence quantum yield and specific chemical properties, making it useful for applications such as fluorescence imaging.

8-(4-bromophenyl)-1,3,5,7-tetramethyl-BODIPY is a derivative based on the BODIPY structure, featuring four methyl groups at positions 1, 3, 5, and 7, with a para-bromophenyl group attached at position 8. This compound finds extensive use in fields such as bioimaging, chemical analysis, and materials science, serving as a fluorescent probe for imaging biological samples, detecting specific chemicals, or in the development of optical materials.

Cy3-PEG7-endo-BCN is a derivative of Cyanine 3 (Cy3) dye that includes seven PEG units. This compound features a lipophilic bidentate macrocyclic ligand, BCN, which allows for further synthesis into macrocyclic complexes. In click chemistry, endo-BCN can react with azide-containing molecules without a catalyst to form a stable triazole.

Cy3-PEG7-exo-BCN is a derivative of the Cyanine 3 (Cy3) dye featuring seven PEG units. This compound includes a lipophilic bidentate macrocyclic ligand, BCN, which can be used for further synthesis of macrocyclic complexes. In click chemistry, exo-BCN reacts with azide-containing molecules to form stable triazoles without the need for a catalyst.

Cy3-PEG7-SCO is a Cyanine 3 (Cy3) dye derivative containing seven PEG units. This compound features an SCO group, enabling covalent bonding with amino groups. SCO is commonly employed to react with amino acid residues of proteins or polypeptides, particularly lysine.

Cy3-PEG7-Azide is a derivative of the Cyanine 3 (Cy3) dye, containing seven PEG units. This compound includes an azide group that enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with molecules containing alkyne groups. Additionally, Cy3-PEG7-Azide can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Ac-Asp-Glu-Val-Asp-pNA is a peptide substrate for caspase-3/7.

Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. Upon enzymatic cleavage by caspase-3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-3 activity. AMC displays excitation emission maxima of 340-360 and 440-460 nm, respectively.

STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016). STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3 References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016).

7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.

DEAC, SE can be used for relevant research in the field of life sciences. Its product number is T64949 and CAS number is 139346-57-9.

7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a useful organic compound for research related to life sciences. The catalog number is T67683 and the CAS number is 96735-88-5.

DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-reactive fluorescent dye with an excitation wavelength (Ex) of 396 nm and an emission wavelength (Em) of 468 nm [1].

Cy3-PEG7-TCO, a Cyanine 3 (Cy3) derivative with 7 polyethylene glycol (PEG) units, facilitates an inverse electron demand Diels-Alder reaction (iEDDA) through its TCO moiety with Tetrazine-functionalized molecules.

MMP-3 Fluorogenic Substrate, a compound designed for matrix metalloproteinase-3 (MMP-3) activity quantification, releases 7-methoxycoumarin-4-acetyl (Mca) upon MMP-3 cleavage. Mca's fluorescence, with excitation and emission maxima at 328 and 420 nm respectively, serves as a measurable indicator of MMP-3 activity.

TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2 3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to the P2X2, P2X4, and P2X7 receptors (IC50 = 2, 15.2, >30 µM, respectively) in HEK293 cells expressing these human receptors. It effectively diminishes acetic acid-induced calcium influx in 1321N1 cells targeting P2X3 and P2X2 3 receptors (IC50 = 100 and 62 nM, respectively) and alleviates pain in a mouse model of visceral pain (ED50 = 6.35 µmol kg). Moreover, TNP-ATP exhibits a notable fluorescence characteristic, with an emission peak at 547 nm after excitation at 403 nm, which enhances four-fold and shifts to 538 nm when bound to the insulin-degrading enzyme (IDE).

Compound 1a, known as 1-(3',6'-Bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-phenylurea, serves as a fast-responsive fluorescent probe for detecting gold ions in water and synthetic products [1].

4-(2-Carboxyphenyl)-7-diethylamino-2-(7-diethylamino-2-oxochroman-3-yl)-chromylium perchlorate is an organic fluorescent dye that features a carboxyl functional group, with an excitation wavelength (λ ex) of approximately 650 nm and an emission wavelength (λ em) of around 690 nm [1].

4-(7-Diethylaminocoumarin-3-yl)benzoyl cyanide (DACB-CN) serves as a multifunctional dye crucial for a wide array of applications. This chemical compound is utilized extensively in biological experiments to monitor and analyze various cellular components and activities. It aids in observing cell structures, tracking biomolecules, assessing cell functions, differentiating cell types, detecting biomolecules, examining tissue pathology, and studying microorganisms. Beyond its scientific research applications, DACB-CN is also employed in traditional industries like textile dyeing and in innovative sectors, including functional textile processing, food pigments, and dye-sensitized solar cells.

7-Diethylamino-3-N-(4-maleimidopropyl)carbamoylcoumarin is a versatile dye utilized across various fields. This compound is primarily important in biological experiments for observing and analyzing cell structures, tracking biomolecules, evaluating cell functions, distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Its applications extend beyond basic scientific research into clinical diagnostics. Additionally, it is employed in traditional industries like textile dyeing and in innovative areas including functional textile processing, food pigments, and dye-sensitized solar cells.