2-(azido-peg-2-amido)-1,3-propandiol

2-(Azido-PEG2-amido)-13-propandiol is a Polyethylene glycol (PEG)-based PROTAC linker used for synthesizing PROTACs[1].

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker used for synthesizing PROTACs [1].

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Azide-PEG3-Tos is a PEG-based PROTAC linker used in the synthesis of PROTACs[1], and a non-cleavable 3-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3-unit PEG ADC linker used for synthesizing antibody-drug conjugates (ADCs) [1] and also functions as a PEG-based PROTAC linker for PROTAC synthesis [2].

Hydroxy-PEG1-C2-methyl ester, a polyethylene glycol (PEG) derived linker, is widely used in the production of PROTACs (proteolysis targeting chimeras). [1]

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2].

N3-PEG3-CH2CH2-Boc is a cleavable 3-unit polyethylene glycol (PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] and also serves as a PEG- and alkyl ether-based PROteolysis TArgeting Chimera (PROTAC) linker for PROTAC molecules[2].

Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

Tetraethylene glycol (PROTAC Linker 18) is a PEG-based linker used in PROTAC synthesis[1].

1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a polyethylene glycol (PEG)-based linker compound suitable for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

BCN-PEG3-Val-Cit is a PEG-based linker widely used in PROTAC synthesis[1] and as a cleavable 3-unit PEG linker in the production of antibody-drug conjugates (ADCs)[2].

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1].

Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthesized E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a linker.

PPC-NHS ester, a cleavable linker crucial in ADC synthesis, facilitates the attachment of cytotoxic drugs to antibodies for precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing the effectiveness of ADCs (Antibody-Drug Conjugates).

YT 6-2 analog-1 (compound 2-3) serves as an autophagy-targeting ligand (ATL) aimed at p62 SQSTM1, useful in synthesizing the AUTOTAC degrader ATC-324 for the Androgen Receptor (AR). ATC-324 promotes the formation of AR p62 complexes, leading to the autophagic-lysosomal degradation of AR. It effectively reduces nuclear AR levels, downregulates the expression of AR and AR-v7 target genes, and can degrade common AR mutants found in prostate cancer (PCa).

E3 Ligase Ligand-linker Conjugate 147 is a conjugate of an E3 ligase ligand and a PROTAC linker, utilized in the synthesis of BRD9 Degrader-1 (Compound 13-7). Comprising the E3 ligase ligand BRD9 ligand-7 and the PROTAC linker 2-((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)ethan-1-ol, this conjugate plays a critical role in biochemical applications.

FLT3 ligand-2 serves as a ligand for the target protein in PROTAC. It is utilized for synthesizing PROTAC FLT-3 degrader 1.

ChREBPα 14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the interaction between carbohydrate response element-binding protein (ChREBP) and 14-3-3 proteins, with an EC50 of 3.8 μM. It effectively safeguards β cells from glucolipotoxicity, preserving cell function and making it relevant for type 2 diabetes research.