(e) si 2

(E)-SI-2 is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. It selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.

MBL-IN-6 (Compound 6d) is a metal-β-lactamase (MBL) inhibitor with Ki values of 2.6 μM for NDM-1 and 0.08 μM for VIM-2. It acts synergistically with Imipenem against clinical isolates producing MBL, such as E. coli SI-M001, K. pneumoniae T2301, and S. marcescens SI-1591, with a MIC ranging from 2-64 μg/mL. MBL-IN-6 does not induce off-target effects and exhibits no inhibitory activity against ACE-1. This compound is useful for research on antibiotic resistance.