(R)-Dinotefuran

(R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, demonstrates insecticidal activities 1.7-2.4 times more effective against typical sucking pests like Aphis gossypii and Apolygus lucorum when compared to its racemic mixtures, by targeting nicotinic acetylcholine receptors. Additionally, (R)-Dinotefuran is effective in managing these pests while posing a reduced risk to honeybees [1].

(S)-Dinotefuran ((S)-MTI-446), a neonicotinoid pesticide, exhibits toxicity through interaction with the α8 subunit of the nAChR in the honeybee Apis mellifera (Apis mellifera Linnaeus). It demonstrates greater toxicity to Apis mellifera compared to its R-dinotefuran counterpart [1].