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TSH Receptor

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T76727 Teprotumumab 1036734-93-6 SDS-PAGE:95.2%;SEC-HPLC:99.6%
Teprotumumab
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. T...
T16403 Org41841 301847-37-0 99.46%
Org41841
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and ...
T5383 D3-βArr 662164-09-2 99.43%
D3-βArr
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSH...
T12192 NCGC00229600 1338824-20-6 99.27%
NCGC00229600
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenous...
T16106 ML224 1338824-21-7 99.14%
ML224
ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.
T13216 TSHR antagonist S37 1217616-61-9 98.35%
TSHR antagonist S37
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
T12073 ML-109 1186649-91-1 98.14%
ML-109
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
T29087 VA-K-14 hydrochloride 1171341-19-7 98.01%
VA-K-14 hydrochloride
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSH...
Teprotumumab
T76727
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. T...
Org41841
T16403
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and ...
D3-βArr
T5383
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSH...
NCGC00229600
T12192
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenous...
ML224
T16106
ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.
TSHR antagonist S37
T13216
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
ML-109
T12073
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
VA-K-14 hydrochloride
T29087
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSH...
TargetMol