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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78971 AMPA receptor modulator-4 2917551-59-6 98%
AMPA receptor modulator-4
AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA recept...
T79191 AMPA receptor modulator-5 2034182-22-2 98%
AMPA receptor modulator-5
AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1].
T79273 NMDA receptor antagonist 6 98%
NMDA receptor antagonist 6
NMDA Receptor Antagonist 6 (Compound 13b) functions as an antagonist at the glycine-binding site of the NMDA receptor and demonstrates cytoneuroprotective effica...
T79374 NMDA receptor antagonist 7 98%
NMDA receptor antagonist 7
Compound (S)-10a, a GluN2B subunit-selective NMDA receptor antagonist, exhibits a K i of 93 nM and an IC 50 of 72 nM. It is potentially useful for research into ...
T79375 NMDA receptor antagonist 8 98%
NMDA receptor antagonist 8
Compound (R)-10a, an NMDA receptor antagonist, exhibits selectivity for the GluN2B subunit, possessing a Ki of 265 nM and an IC50 of 62 nM. This compound is util...
T79504 AMPA receptor modulator-6 516491-33-1 98%
AMPA receptor modulator-6
AMPA receptor modulator-6, an AMPA receptor positive allosteric modulator (PAM), is utilized in the research of neurological diseases [1].
T79611 DQP-26 1449373-99-2 98%
DQP-26
DQP-26, a potent negative allosteric modulator of NMDA receptors (NMDARs), exhibits IC50 values of 0.77 μM for GluN2C and 0.44 μM for GluN2D subunits, indicating...
T79855 Nevadistinel 2181816-92-0 98%
Nevadistinel
Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, indicated for mitigating cognitive deficits rela...
T79857 Risevistinel 2591344-26-0 98%
Risevistinel
Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative conditi...
T79959 6-Hydroxykynurenic acid 3778-29-8 98%
6-Hydroxykynurenic acid
6-Hydroxykynurenic acid (6-HKA), a kynurenic acid (KYNA) derivative isolated from Ginkgo leaves, functions as a low-affinity NMDAR antagonist with an IC50 of 59 ...
T81409 Pregnanolone sulfate (pyridinium) 124107-39-7 98%
Pregnanolone sulfate (pyridinium)
Pregnanolone sulfate pyridinium, an endogenous neurosteroid, inhibits NMDA receptors and exhibits neuroprotective properties [1].
T81899 LY836 98%
LY836
LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons. It has potential applications in th...
T81912 LSP-GR3 1235945-37-5 98%
LSP-GR3
LSP-GR3, a novel splice modulating oligomer (SMO) consisting of chemically-modified RNA oligonucleotides, potently and specifically directs the alternative splic...
T16800 (RS)-AMPA 77521-29-0 98%
(RS)-AMPA
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.
T15684 L-689560 139051-78-8 98%
L-689560
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
T23490 UBP310 902464-46-4 98%
UBP310
UBP310 (UBP 310) is a GLUK5 kainate receptor antagonist
T5819 Rapastinel Trifluoroacetate 1435786-04-1 99.96%
Rapastinel Trifluoroacetate
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
T3320 Dizocilpine Maleate 77086-22-7 99.96%
Dizocilpine Maleate
Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membran...
T4979 Procyclidine hydrochloride 1508-76-5 99.95%
Procyclidine hydrochloride
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.
T16402 Org-26576 1026791-61-6 99.94%
Org-26576
Org-26576 is a positive allosteric modulator of the AMPA receptor.
AMPA receptor modulator-4
T78971
AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA recept...
AMPA receptor modulator-5
T79191
AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1].
NMDA receptor antagonist 6
T79273
NMDA Receptor Antagonist 6 (Compound 13b) functions as an antagonist at the glycine-binding site of the NMDA receptor and demonstrates cytoneuroprotective effica...
NMDA receptor antagonist 7
T79374
Compound (S)-10a, a GluN2B subunit-selective NMDA receptor antagonist, exhibits a K i of 93 nM and an IC 50 of 72 nM. It is potentially useful for research into ...
NMDA receptor antagonist 8
T79375
Compound (R)-10a, an NMDA receptor antagonist, exhibits selectivity for the GluN2B subunit, possessing a Ki of 265 nM and an IC50 of 62 nM. This compound is util...
AMPA receptor modulator-6
T79504
AMPA receptor modulator-6, an AMPA receptor positive allosteric modulator (PAM), is utilized in the research of neurological diseases [1].
DQP-26
T79611
DQP-26, a potent negative allosteric modulator of NMDA receptors (NMDARs), exhibits IC50 values of 0.77 μM for GluN2C and 0.44 μM for GluN2D subunits, indicating...
Nevadistinel
T79855
Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, indicated for mitigating cognitive deficits rela...
Risevistinel
T79857
Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative conditi...
6-Hydroxykynurenic acid
T79959
6-Hydroxykynurenic acid (6-HKA), a kynurenic acid (KYNA) derivative isolated from Ginkgo leaves, functions as a low-affinity NMDAR antagonist with an IC50 of 59 ...
Pregnanolone sulfate (pyridinium)
T81409
Pregnanolone sulfate pyridinium, an endogenous neurosteroid, inhibits NMDA receptors and exhibits neuroprotective properties [1].
LY836
T81899
LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons. It has potential applications in th...
LSP-GR3
T81912
LSP-GR3, a novel splice modulating oligomer (SMO) consisting of chemically-modified RNA oligonucleotides, potently and specifically directs the alternative splic...
(RS)-AMPA
T16800
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.
L-689560
T15684
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
UBP310
T23490
UBP310 (UBP 310) is a GLUK5 kainate receptor antagonist
Rapastinel Trifluoroacetate
T5819
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
Dizocilpine Maleate
T3320
Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membran...
Procyclidine hydrochloride
T4979
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.
Org-26576
T16402
Org-26576 is a positive allosteric modulator of the AMPA receptor.
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TargetMol