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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2S2264 Linalool 78-70-6 98.95%
Linalool
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
T1738 Taxifolin 480-18-2 98.9%
Taxifolin
Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
T2367 SKF-86002 72873-74-6 98.89%
SKF-86002
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
T10866 Cot inhibitor-2 915363-56-3 98.87%
Cot inhibitor-2
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
T29857 Alethine 646-08-2 98.82%
Alethine
Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TN...
T10730 CDC801 192819-27-5 98.81%
CDC801
CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
TN1132 Procyanidin A2 41743-41-3 98.78%
Procyanidin A2
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 ...
TN1579 Dihydrocucurbitacin B 13201-14-4 98.67%
Dihydrocucurbitacin B
Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) is isolated from the roots of Cayaponia tayuya with anti-cancer activity.
TN1291 7,3',4'-Tri-O-methylluteolin 29080-58-8 98.66%
7,3',4'-Tri-O-methylluteolin
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitry...
TN1475 Caulophyllogenin 52936-64-8 98.56%
Caulophyllogenin
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
T11742 K-7174 191089-59-5 98.55%
K-7174
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
T8692 (Rac)-Benpyrine 1333714-43-4 98.55%
(Rac)-Benpyrine
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
T1125 Shikonin 517-89-5 98.54%
Shikonin
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
TN1520 Isoforskolin 64657-21-2 98.51%
Isoforskolin
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used...
TN2309 Withanolide A 32911-62-9 98.49%
Withanolide A
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
T8440 LASSBio-1135 852453-71-5 98.43%
LASSBio-1135
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
T2384 Pomalidomide 19171-19-8 98.4%
Pomalidomide
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T2879 Fisetin 528-48-3 98.31%
Fisetin
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
T77494 TNF-α-IN-9 2054199-25-4 98.28%
TNF-α-IN-9
TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
T10865L Cot inhibitor-1 hydrochloride T10865L 98.26%
Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
Linalool
T2S2264
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
Taxifolin
T1738
Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
SKF-86002
T2367
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
Cot inhibitor-2
T10866
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
Alethine
T29857
Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TN...
CDC801
T10730
CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
Procyanidin A2
TN1132
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 ...
Dihydrocucurbitacin B
TN1579
Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) is isolated from the roots of Cayaponia tayuya with anti-cancer activity.
7,3',4'-Tri-O-methylluteolin
TN1291
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitry...
Caulophyllogenin
TN1475
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
K-7174
T11742
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
(Rac)-Benpyrine
T8692
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
Shikonin
T1125
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
Isoforskolin
TN1520
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used...
Withanolide A
TN2309
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
LASSBio-1135
T8440
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
Pomalidomide
T2384
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
Fisetin
T2879
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
TNF-α-IN-9
T77494
TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
Cot inhibitor-1 hydrochloride
T10865L
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
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