T5561 |
TLR7/8 agonist 1 dihydrochloride
|
1620278-72-9
|
98%
|
|
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.
|
T22698 |
TLR3-IN-1
|
1279713-77-7
|
97.77%
|
|
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways ...
|
T5S0167 |
Atractylenolide I
|
73069-13-3
|
97.55%
|
|
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
|
T10833 |
CL264
|
1510712-69-2
|
97.14%
|
|
CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.
|
T37292 |
M62812
|
613263-00-6
|
96.85%
|
|
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects ...
|
T7860 |
SM-324405
|
677773-91-0
|
96.44%
|
|
SM-324405 is an agonist of TLR7.
|
TP1067 |
Pam3CSK4 TFA (112208-00-1 free base)
|
112208-01-2
|
96.4%
|
|
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
|
T29099L |
VB 201
|
630112-41-3
|
100%
|
|
VB 201 is an oxidized phospholipid small molecule with anti-inflammatory activity that inhibits CD14 and Toll-like receptor 2-dependent innate cell activation an...
|
T9645 |
CU-115
|
2471982-20-2
|
100%
|
|
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β...
|
T77353 |
MyD88-IN-1
|
2911609-80-6
|
100%
|
|
MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pat...
|
T3898 |
Schaftoside
|
51938-32-0
|
100%
|
|
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
|
TJS1779 |
Protosappanin A
|
102036-28-2
|
100%
|
|
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
|
T34249 |
Rabeximod
|
872178-65-9
|
100%
|
|
Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by ...
|
TP1938L |
RS09 2TFA (1449566-36-2 free base)
|
TP1938L
|
100%
|
|
RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in...
|
T12516 |
Polyinosinic-polycytidylic acid sodium
|
42424-50-0
|
|
|
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic...
|
T11598 |
IAXO-102
|
1115270-63-7
|
|
|
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
|
T23171 |
Polyinosinic-polycytidylic acid
|
24939-03-5
|
|
|
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mamm...
|
T3795 |
Corilagin
|
23094-69-1
|
|
|
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
|
T8503 |
TLR4-IN-C34
|
40592-88-9
|
|
|
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
|
T60052 |
BMS-905
|
2205846-49-5
|
98%
|
|
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
|