Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.

Cat. No.	Product name	CAS No.	Purity
T6594	MNS	1485-00-3	98%
T6594	MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T23128	PD180970	287204-45-9	98%
T23128	PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies...
T37603L	Osteogenic Growth Peptide (10-14) acetate		98%
T37603L	Osteogenic Growth Peptide (10-14) acetate is a Src inhibitor and an effective mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide...
T23176	PP 3	5334-30-5	98%
T23176	PP 3 is a Negative control for the Src kinase inhibitor PP 2
T17267	XL228	898280-07-4	98%
T17267	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T6732	WYE-687	1062161-90-3	98%
T6732	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
T6315	MLN8054	869363-13-3	98%
T6315	MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T2709	TAK-901	934541-31-8	98%
T2709	TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others....
T6077	ZM-447439	331771-20-1	98%
T6077	ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective f...
T6419	BMS-536924	468740-43-4	98%
T6419	BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
T2153	1-NM-PP1	221244-14-0	98%
T2153	1 nM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
T13824	PP58	212391-58-7	98%
T13824	PP58 is an inhibitor of PDGFR, FGFR and Src family.
T2070	Agerafenib	1188910-76-0	98%
T2070	CEP-32496 is a highly potent inhibitor of BRAF.
T8995	NCGC00262650	344359-25-7	98%
T8995	NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
T23127	PD-161570	192705-80-9	98%
T23127	FGFR inhibitor
T6982	SGI-7079	1239875-86-5	98%
T6982	SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR...
T16760	RK-24466	213743-31-8	98%
T16760	RK-24466 is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
T3063	PD173955	260415-63-2	98%
T3063	PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC...
T1754	ZM 306416	690206-97-4	98%
T1754	ZM 306416, a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).
T6057	URMC-099	1229582-33-5	98%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...