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By Target- PI3K
- Src(1)
- mTOR(1)
- p38 MAPK(1)
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Results for "
target/Src/3
" in TargetMol Product Catalog- Inhibitors & Agonists1
- Compound Libraries1
wye-687 
T67321062161-90-3
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1 pS6K(T389) and mTORC2 P-AKT(S473) without affecting P-AKT(T308). Its selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
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T722701702364-87-1
WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC50 values of 81 nM and 3.11 μM, respectively.
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