PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Cat. No.	Product name	CAS No.	Purity
T9593	Senaparib	1401682-78-7	99.41%
T9593	Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.
T12064	Niraparib (R-enantiomer)	1038915-58-0	99.41%
T12064	Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).
T8806	Fluzoparib	1358715-18-0	99.38%
T8806	Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.
T12695	RBN-2397	2381037-82-5	99.36%
T12695	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.
T1807	JW 55	664993-53-7	99.36%
T1807	JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2)...
T9024	OUL35	6336-34-1	99.3%
T9024	OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
T22264	AZ9482	1825345-33-2	99.29%
T22264	AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centro...
T6366	A-966492	934162-61-5	99.25%
T6366	A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.
TN1891	Lupiwighteone	104691-86-3	99.20%
TN1891	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T72553	ARTD10/PARP10-IN-1	1708103-76-7	99.14%
T72553	ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ART...
T6127	Rucaparib Phosphate	459868-92-9	99.1%
T6127	Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemothe...
T4241	Rubiadin	117-02-2	99.1%
T4241	Rubiadin (1,3-Dihydroxy-2-Methylanthracene-9,10-Dione) possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydro...
T9497	Niraparib tosylate monohyrate	1613220-15-7	99.09%
T9497	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, en...
T73027	PARP-2-IN-3	2915650-86-9	99.08%
T73027	PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for...
T1878	XAV-939	284028-89-3	99.04%
T1878	XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcript...
T73496	OUL232	943119-42-4	99.04%
T73496	OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.
T7443	4'-Methoxychalcone	959-23-9	98.93%
T7443	4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
TN1416	Ayanin	572-32-7	98.9%
TN1416	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylethe...
T2124	PJ34 hydrochloride	344458-15-7	98.87%
T2124	PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.
T6181	UPF 1069	1048371-03-4	98.84%
T6181	UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.