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Neurokinin receptor

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TP1572 GR-73632 133156-06-6 99.68%
GR-73632
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
T3034 Eprazinone dihydrochloride 10402-53-6 99.25%
Eprazinone dihydrochloride
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect.
T7631L Eledoisin Related Peptide 2TFA T7631L 99%
Eledoisin Related Peptide 2TFA
Eledoisin Related Peptide 2TFA (Eledoisin Related Peptide 2TFA (2990-43-4(free base))) is a tachykinin receptor ligand.
T13329L Vofopitant dihydrochloride 168266-51-1 98.99%
Vofopitant dihydrochloride
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values ...
T15278 Fezolinetant 1629229-37-3 98.62%
Fezolinetant
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
TP2227L C14TKL-1 acetate TP2227L 98.56%
C14TKL-1 acetate
C14TKL-1 acetate is a NK1 receptor agonist.
TP1363L Neurokinin B acetate(86933-75-7 free base) TP1363L 98.53%
Neurokinin B acetate(86933-75-7 free base)
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1...
T3724 Rolapitant hydrochloride 858102-79-1 98.46%
Rolapitant hydrochloride
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapita...
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base) TP1772L 98.33%
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 recep...
TP1087 Substance P 33507-63-0 98%
Substance P
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
T7549 Talnetant 174636-32-9 98%
Talnetant
Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic ...
T7209 Maropitant 147116-67-4 98%
Maropitant
Maropitant is a selective neurokinin (NK1) receptor antagonist.
T22811L GR 94800 acetate 97.86%
GR 94800 acetate
GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
TP1899L1 Hemokinin 1 (human) acetate(491851-53-7 free base) TP1899L1 97.82%
Hemokinin 1 (human) acetate(491851-53-7 free base)
Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM ...
T13329 Vofopitant 168266-90-8 97.61%
Vofopitant
Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
T1790 Fosaprepitant dimeglumine 265121-04-8 97.39%
Fosaprepitant dimeglumine
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic act...
T68068L (R)-CJ 11974 187281-35-2 97.03%
(R)-CJ 11974
(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induc...
T68068 Ezlopitant 147116-64-1 97.03%
Ezlopitant
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
TP1862L [Sar9] Substance P acetate(77128-75-7 free base) TP1862L 96.67%
[Sar9] Substance P acetate(77128-75-7 free base)
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)1...
TP1738L Kassinin acetate(63968-82-1 free base) TP1738L 95.81%
Kassinin acetate(63968-82-1 free base)
Kassinin acetate is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.
GR-73632
TP1572
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
Eprazinone dihydrochloride
T3034
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect.
Eledoisin Related Peptide 2TFA
T7631L
Eledoisin Related Peptide 2TFA (Eledoisin Related Peptide 2TFA (2990-43-4(free base))) is a tachykinin receptor ligand.
Vofopitant dihydrochloride
T13329L
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values ...
Fezolinetant
T15278
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
C14TKL-1 acetate
TP2227L
C14TKL-1 acetate is a NK1 receptor agonist.
Neurokinin B acetate(86933-75-7 free base)
TP1363L
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1...
Rolapitant hydrochloride
T3724
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapita...
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
TP1772L
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 recep...
Substance P
TP1087
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Talnetant
T7549
Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic ...
Maropitant
T7209
Maropitant is a selective neurokinin (NK1) receptor antagonist.
GR 94800 acetate
T22811L
GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
Hemokinin 1 (human) acetate(491851-53-7 free base)
TP1899L1
Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM ...
Vofopitant
T13329
Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
Fosaprepitant dimeglumine
T1790
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic act...
(R)-CJ 11974
T68068L
(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induc...
Ezlopitant
T68068
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
[Sar9] Substance P acetate(77128-75-7 free base)
TP1862L
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)1...
Kassinin acetate(63968-82-1 free base)
TP1738L
Kassinin acetate is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.
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TargetMol