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Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11931 MA242 1049704-18-8 98%
MA242
MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
TN4341 IVHD-valtrate 28325-56-6 98%
IVHD-valtrate
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
T14203 AM-8735 1429386-01-5 98%
AM-8735
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
T12027 MG-277 T12027 98%
MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T12031 MI-1061 1410737-34-6 98%
MI-1061
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
T16888 SJ-172550 431979-47-4 99.87%
SJ-172550
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T67698 P53-Mdm2 inhibitor 4 350678-63-6 99.63%
p53-Mdm2 inhibitor 4
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
T28078 MMRi64 430458-66-5 99.61%
MMRi64
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel...
T1919 Tenovin-1 380315-80-0 99.44%
Tenovin-1
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T21773 SP-141 1253491-42-7 99.21%
SP-141
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
T6610 XI-006 58131-57-0 99.12%
XI-006
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T6254 Idasanutlin 1229705-06-9 99.01%
Idasanutlin
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
TQ0231 NVP-CGM097 1313363-54-0 98.92%
NVP-CGM097
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
T3517 RO8994 1309684-94-3 98.87%
RO8994
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
TQ0127 Navtemadlin 1352066-68-2 98.86%
Navtemadlin
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T6614 Nutlin-3b 675576-97-3 98.83%
Nutlin-3b
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
T14303 Alrizomadlin 1818393-16-6 98.79%
Alrizomadlin
Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and...
T2179 Triptolide 38748-32-2 98.52%
Triptolide
Triptolide (PG490) is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T72026 P53-MDM2-IN-1 381717-91-5 98.3%
p53-MDM2-IN-1
p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an K i value of 23.35 µM. p53-MDM2-IN-1 can be used for anti-tumor research .
MA242
T11931
MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
IVHD-valtrate
TN4341
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
AM-8735
T14203
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
MG-277
T12027
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
MI-1061
T12031
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
SJ-172550
T16888
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
p53-Mdm2 inhibitor 4
T67698
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
MMRi64
T28078
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel...
Tenovin-1
T1919
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
SP-141
T21773
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
XI-006
T6610
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Idasanutlin
T6254
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
NVP-CGM097
TQ0231
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
RO8994
T3517
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
Navtemadlin
TQ0127
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
Nutlin-3b
T6614
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
Alrizomadlin
T14303
Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and...
Triptolide
T2179
Triptolide (PG490) is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
p53-MDM2-IN-1
T72026
p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an K i value of 23.35 µM. p53-MDM2-IN-1 can be used for anti-tumor research .
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TargetMol