HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
T6855	HA15	1609402-14-3	98%
T6855	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T2444	KNK437	218924-25-5	98%
T2444	KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
T7265	HSP27 inhibitor J2	2133499-85-9	98%
T7265	HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of ...
T7261	Grp94 Inhibitor-1	2234897-35-7	98%
T7261	Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
T6118	NVP-HSP990	934343-74-5	97.63%
T6118	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
T72076	H2-Gamendazole	877768-84-8	97.36%
T72076	H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and...
T18018	HS-27	1562024-11-6	97.09%
T18018	HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
T8668	HM03	500565-15-1	96.96%
T8668	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.
T0756	Ethoxyquin	91-53-2	95.94%
T0756	Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
T8189	Dihydroberberine	483-15-8	93.77%
T8189	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T27193	DN401	2135749-60-7	100%
T27193	DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.
T13547L	AMP-PCP disodium	7414-56-4	100%
T13547L	AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contribut...
T20890	Alvespimycin	467214-20-6	100%
T20890	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.
T12896L	Shepherdin 79-87 acetate
T12896L	Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
T21883	Gedunin	2753-30-2
T21883	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
TQ0280	Feretoside	27530-67-2
TQ0280	Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).
T2230	Paeoniflorin	23180-57-6
T2230	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
TP1496L	P5 Ligand for Dnak and DnaJ acetate	TP1496L
TP1496L	p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).
T3527	TRC051384	867164-40-7	98%
T3527	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic s...
T6343	Geldanamycin	30562-34-6	98%
T6343	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.