T4338 |
USP7/USP47 inhibitor
|
1247825-37-1
|
98.5%
|
|
USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively...
|
T9375 |
IU1-248
|
2307472-03-1
|
98.49%
|
|
IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].
|
T9217 |
USP7-IN-8
|
2009273-60-1
|
98.48%
|
|
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
|
T72784 |
OTUB1/USP8-IN-1
|
2858800-98-1
|
98.47%
|
|
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/...
|
T12024 |
MF-094
|
2241025-68-1
|
98.46%
|
|
MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).
|
T2424 |
P 22077
|
1247819-59-5
|
98.42%
|
|
P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
|
T73151 |
USP22-IN-1
|
309735-96-4
|
98.2%
|
|
USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.
|
T11209 |
EOAI3402143
|
1699750-95-2
|
98.09%
|
|
EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knoc...
|
T11485 |
GSK2643943A
|
2449301-27-1
|
98.06%
|
|
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
|
T60146 |
USP8-IN-1
|
2477650-96-5
|
98.01%
|
|
USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].
|
T3088 |
N-Ethylmaleimide
|
128-53-0
|
98%
|
|
N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.
|
T1902 |
BAY 11-7082
|
19542-67-7
|
97.91%
|
|
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-s...
|
T1924 |
LDN-57444
|
668467-91-2
|
97.8%
|
|
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
|
T14852 |
C527
|
192718-06-2
|
97.64%
|
|
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
|
T6697 |
TCID
|
30675-13-9
|
97.16%
|
|
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
|
T11110 |
DUB-IN-1
|
924296-18-4
|
97.11%
|
|
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
|
T1932 |
B-AP15
|
1009817-63-3
|
95.07%
|
|
B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating ac...
|
T15729 |
LDN-91946
|
439946-22-2
|
92.78%
|
|
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
|
T28284 |
P22074
|
90680-28-7
|
100%
|
|
P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.
|
T8464 |
RA-9
|
919091-63-7
|
|
|
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
|