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DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1241 Altretamine 645-05-6 98%
Altretamine
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
T9985 Methyl methanesulfonate 66-27-3 98%
Methyl methanesulfonate
Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and rep...
T73457 DN-1289 98%
DN-1289
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 4...
T1507 Streptozocin 18883-66-4 98%
Streptozocin
Streptozocin (NSC-85998) is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimen...
T6057 URMC-099 1229582-33-5 98%
URMC-099
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
Altretamine
T1241
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
Methyl methanesulfonate
T9985
Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and rep...
DN-1289
T73457
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 4...
Streptozocin
T1507
Streptozocin (NSC-85998) is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimen...
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
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TargetMol