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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5759 S-(+)-Marmesin 13849-08-6 98.00%
S-(+)-Marmesin
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T8236 RHC 80267 83654-05-1 98%
RHC 80267
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
T3981 Acacetin 480-44-4 98%
Acacetin
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity...
T0441 Pasiniazid 2066-89-9 98%
Pasiniazid
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
T5758 Sphondin 483-66-9 98%
sphondin
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of...
T5688 Micheliolide 68370-47-8 98%
Micheliolide
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T2856 (-)-Epicatechin 490-46-0 98%
(-)-Epicatechin
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization o...
T5681 ETHYL CAFFEATE 102-37-4 98%
ETHYL CAFFEATE
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely block...
T8505 SC-236 170569-86-5 98%
SC-236
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
T7540 2,5-Di-tert-butylhydroquinone 88-58-4 98%
2,5-Di-tert-butylhydroquinone
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
T0159 Pranoprofen 52549-17-4 97.99%
Pranoprofen
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
T0055 Glafenine 3820-67-5 97.97%
Glafenine
Glafenine (Glafenin), a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various orig...
T0646 5-Aminosalicylic Acid 89-57-6 97.88%
5-Aminosalicylic Acid
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
T7033 Rosmanol 80225-53-2 97.79%
Rosmanol
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activi...
T22092 Indomethacin heptyl ester 282728-47-6 97.66%
Indomethacin heptyl ester
Indomethacin heptyl ester is a non-selective inhibitor of both COX-1 and COX-2
T2S1625 (E)-Ethyl p-methoxycinnamate 24393-56-4 97.56%
(E)-Ethyl p-methoxycinnamate
1. (E)-Ethyl p-methoxycinnamate (EPMC) is an anticarcinogenic agent. 2. (E)-Ethyl p-methoxycinnamate (EPMC) is a glutathion S tranferase inhibitor.
T6970 RK33 1070773-09-9 97.55%
RK33
RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sen...
T2972 Rutaecarpine 84-26-4 97.54%
Rutaecarpine
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
T16169 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 4272-74-6 97.44%
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
TN2440 Sinapyl alcohol 537-33-7 97.28%
Sinapyl alcohol
Technical grade is a natural from Magnolia sieboldii
S-(+)-Marmesin
T5759
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
RHC 80267
T8236
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
Acacetin
T3981
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity...
Pasiniazid
T0441
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
sphondin
T5758
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of...
Micheliolide
T5688
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
(-)-Epicatechin
T2856
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization o...
ETHYL CAFFEATE
T5681
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely block...
SC-236
T8505
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
2,5-Di-tert-butylhydroquinone
T7540
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
Pranoprofen
T0159
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
Glafenine
T0055
Glafenine (Glafenin), a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various orig...
5-Aminosalicylic Acid
T0646
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
Rosmanol
T7033
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activi...
Indomethacin heptyl ester
T22092
Indomethacin heptyl ester is a non-selective inhibitor of both COX-1 and COX-2
(E)-Ethyl p-methoxycinnamate
T2S1625
1. (E)-Ethyl p-methoxycinnamate (EPMC) is an anticarcinogenic agent. 2. (E)-Ethyl p-methoxycinnamate (EPMC) is a glutathion S tranferase inhibitor.
RK33
T6970
RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sen...
Rutaecarpine
T2972
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
T16169
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
Sinapyl alcohol
TN2440
Technical grade is a natural from Magnolia sieboldii
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TargetMol