T11944 |
Maritoclax
|
1227962-62-0
|
97.70%
|
|
Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value o...
|
T5346 |
S63845
|
1799633-27-4
|
97.7%
|
|
S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)
|
T14071 |
A-385358
|
406228-55-5
|
97.40%
|
|
A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.
|
TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
T10487 |
BCL6-IN-3
|
2253878-44-1
|
97.25%
|
|
BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has...
|
T10483 |
Lisaftoclax
|
2180923-05-9
|
97.14%
|
|
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lis...
|
T6396 |
(R)-(-)-Gossypol acetic acid
|
866541-93-7
|
96.73%
|
|
(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0...
|
TP1724L |
PUMA BH3 acetate
|
|
96.64%
|
|
PUMA BH3 acetate (PUMA BH3 Free base) is a p53 positive regulator of apoptosis (PUMA) BH3 domain polypeptide that acts as a direct activator of Bak with a Kd of ...
|
T0448 |
(S)-(+)-Ibuprofen
|
51146-56-6
|
100%
|
|
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
|
TN1918 |
Medicarpin
|
32383-76-9
|
|
|
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
|
T60008 |
BCL6-IN-6
|
2408882-54-0
|
98%
|
|
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressor...
|
T3940 |
CID5721353
|
301356-95-6
|
98%
|
|
CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bin...
|
TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
T14846 |
Bz 423
|
216691-95-1
|
98%
|
|
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c rele...
|
T2632 |
A-1210477
|
1668553-26-1
|
98%
|
|
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
|
T6281 |
TW-37
|
877877-35-5
|
98%
|
|
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).
|
T77332 |
TV 3279
|
209394-29-6
|
98%
|
|
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SO...
|
T25049 |
Allethrin
|
584-79-2
|
98%
|
|
Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent.
|
T5408 |
BI-3802
|
2166387-65-9
|
98%
|
|
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. BI-3802 induces the polymerization of BCL...
|
TN1195 |
17-Hydroxy sprengerinin C
|
1029017-75-1
|
98%
|
|
17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C ...
|