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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T1942	DMH-1	1206711-16-1	99.7%
T1942	DMH-1 is a potent and selective BMP inhibitor.
T8399	Crizotinib hydrochloride	1415560-69-8	99.67%
T8399	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T3079	GSK1838705A	1116235-97-2	99.63%
T3079	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T8387	Alectinib hydrochloride	1256589-74-8	99.61%
T8387	Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
T3678	Entrectinib	1108743-60-7	99.61%
T3678	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1....
T10287	ALK2-IN-2	2254409-25-9	99.55%
T10287	ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.
T6496	Vactosertib	1352608-82-2	99.55%
T6496	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
T14997	Conteltinib	1384860-29-0	99.54%
T14997	Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hy...
T4257	Belizatinib	1357920-84-3	99.48%
T4257	Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T1791	Ceritinib	1032900-25-6	99.46%
T1791	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1900	LDN-212854	1432597-26-6	99.38%
T1900	LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2...
T1661	Crizotinib	877399-52-5	99.35%
T1661	Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T2098	A 77-01	607737-87-1	99.31%
T2098	A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T22324	Ensartinib hydrochloride	2137030-98-7	99.29%
T22324	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known cr...
T1914	K02288	1431985-92-0	99.27%
T1914	K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T9837	N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline	1352608-94-6	99.27%
T9837	Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
T9947	GW-6604	452342-37-9	99.26%
T9947	GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
T10759	CEP-28122 mesylate salt (1022958-60-6 free base)	T10759	99.19%
T10759	CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
T11184	EML4-ALK kinase inhibitor 1	1373409-08-5	99.14%
T11184	EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lympho...
T1967	AZD-3463	1356962-20-3	99.13%
T1967	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.