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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T61424	OD36 hydrochloride	2387510-88-3	99.85%
T61424	OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
T13138	TGFBR1-IN-1	2170830-26-7	98%
T13138	TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T15262	Vactosertib Hydrochloride	1352610-25-3	98%
T15262	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T10283	ALK-IN-5	2351929-66-1	98%
T10283	ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T13781	MS4077	2230077-10-6	98%
T13781	MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442	A 83-01 sodium salt	2828431-89-4	98%
T10442	A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13421	(-)-Cevimeline hydrochloride hemihydrate	T13421	98%
T13421	(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
T10426	AZ12601011	2748337-86-0	98%
T10426	AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
T1791L	Ceritinib dihydrochloride	1380575-43-8	99.99%
T1791L	Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ...
T1936	Alectinib	1256580-46-7	99.97%
T1936	Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T3061	Lorlatinib	1454846-35-5	99.93%
T3061	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
T2251	NVP-TAE 684	761439-42-3	99.91%
T2251	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T8152	6-Demethoxytangeretin	6601-66-7	99.89%
T8152	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T1726	SB-431542	301836-41-9	99.87%
T1726	SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
T4071	Repotrectinib	1802220-02-5	99.86%
T4071	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
T1944	LDN-214117	1627503-67-6	99.85%
T1944	LDN-214117 is a potent and selective ALK2 inhibitor.
T4975	SM 16	614749-78-9	99.81%
T4975	SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T2449	D4476	301836-43-1	99.8%
T2449	D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T35348	LDN-193189 2HCl	1435934-00-1	99.78%
T35348	LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
T16708	R-268712	879487-87-3	99.77%
T16708	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...