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WCY-8-67 TFA
T212843L
WCY-8-67 TFA is an orally bioavailable selective USP5 inhibitor with an IC₅₀ of 1.33 μM. It induces apoptosis in vitro and inhibits the JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA suppresses the proliferation of AE-positive acute myeloid leukemia (AML) cells, induces G1 phase cell cycle arrest, and promotes cell differentiation. It shows significant anti-leukemic activity in mouse in vivo experiments and can be used in AML research.
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