valproic acid

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that suppresses HDAC1 activity and induces HDAC2 degradation, exhibiting oral bioavailability. Valproic Acid activates Notch1 signalling and inhibits the proliferation of small cell lung carcinoma cells, making it applicable for research into epilepsy and bipolar disorder.

Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, Valproic acid sodium salt increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproic acid sodium salt may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.

2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.

Valproic acid hydroxamate (VPA-HA) exhibits anticonvulsant activity in a mouse model of neural tube defects and lacks teratogenic activity.

Valproic acid methyl ester-d3 is the deuterium-labeled version of Valproic acid methyl ester.

Valproic acid impurity 1 is a contaminant of Valproic acid.

2,4-Diene-valproic acid (2,4-VPA) is a methyl-branched fatty acid and a metabolite of Valproic acid.

2-Ene-valproic acid-CoA (2-Ene-valproic acid-coenzyme A) is a derivative of coenzyme A.

3-Oxo-valproic acid-CoA (3-Oxo-valproic acid coenzyme A) is a derivative of coenzyme A.

Valproic acid-CoA (Valproic acid coenzyme A) is a derivative of coenzyme A.

2,3-Diene-valproicacid-CoA (2,3-Diene-valproicacid-coenzyme A) is a derivative of coenzyme A.

3-Hydroxyvalproic acid (3-Hydroxy VPA) is a metabolite of valproic acid. It acts as a mild inhibitor of enzymes related to the mitochondrial β-oxidation pathway. This compound holds potential for research in disorders associated with abnormalities in valproic acid metabolism.

Valproic acid magnesium (Magnesium valproate) is an orally active HDAC inhibitor with an IC50 ranging from 0.5 to 2 mM. It suppresses the activity of HDAC1 (IC50, 400 μM) and induces the degradation of HDAC2. Additionally, it activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid magnesium is applicable in research on epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraines.

Valproic Acid-D15 is a deuterated compound of Valproic Acid. Valproic Acid (T7064) has a CAS number of 99-66-1. Valproic Acid (T7064) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid (T7064) have not been completely elucidated. Valproic Acid (T7064) has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid (T7064) is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid (T7064) is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Valproic acid-D14 sodium is the deuterated form of Valproic acid (sodium). Valproic acid sodium (T1602) salt (Sodium Valproate) acts as an HDAC inhibitor, with an IC50 range of 0.5-2 mM, and inhibits the activity of HDAC1 (IC50, 400 μM) while also promoting the degradation of HDAC2. It activates the Notch1 signaling pathway and suppresses the proliferation of small cell lung cancer (SCLC) cells. Additionally, Valproic acid sodium (T1602) salt is applicable in research related to epilepsy, bipolar disorder, and migraines.

Valproic Acid-D4 is a deuterated compound of Valproic Acid. Valproic Acid (T7064) has a CAS number of 99-66-1. Valproic Acid (T7064) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid (T7064) have not been completely elucidated. Valproic Acid (T7064) has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid (T7064) is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid (T7064) is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Valproic Acid (Standard) is a reference standard for research and analysis in studies involving Valproic Acid. Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that suppresses HDAC1 activity and induces HDAC2 degradation, exhibiting oral bioavailability. Valproic Acid activates Notch1 signalling and inhibits the proliferation of small cell lung carcinoma cells, making it applicable for research into epilepsy and bipolar disorder.

Valproic Acid-D15 (Standard) is a reference standard of Valproic Acid-D15 intended for quantitative analysis, quality control, and related biochemical research applications. Valproic Acid-d15 is a deuterated compound of Valproic Acid. Valproic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Valproic Acid-D4 (Standard) is a reference standard of Valproic Acid-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Valproic Acid-d4 is a deuterated compound of Valproic Acid. Valproic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor, Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.

3-Hydroxyvalproicacid-CoA (3-Hydroxyvalproic acid coenzyme A) is a derivative of coenzyme A.

Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.

Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.

1. p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.