t2588

Cefteram pivoxil (T-2588) (CFTM-PI) is an oral antibiotic available in powder suspension and tablet formulations indicated in China for the treatment of bacterial infections. 

Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.

NSC103054 is an A-ring dibrominated derivative of 17β-estradiol and acts as an inhibitor of ABCG2 transporter function (IC50=20–30 μM). NSC103054 modulates ABCG2/BCRP transporters by inhibiting ABCG2 activity and can be used in breast cancer research.

Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.

NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro.