t 20

T20-M is a precursor peptide with strong binding affinity for UBE2C.

Dextran T20 (MW 20,000) is a polymer of dehydrated glucose with an average molecular weight of 20,000. It exhibits excellent biodegradability and biocompatibility, making it suitable for use in food, pharmaceuticals, cosmetics, and research fields.

Enfuvirtide is an anti-HIV-1 fusion peptide that inhibits HIV p24 antigen and Gag gene expression in macrophages.

Enfuvirtide acetate salt is a linear synthetic peptide made of 36 amino acids. It has an acetylated N-terminus and a carboxamide C-terminus.

t-Boc-N-Amido-PEG20-amine (Boc-NH-PEG20-CH2CH2NH2) is a compound comprising NH2, PEG units, and t-Boc-N-Amido, utilized in drug delivery applications.

Antitrypanosomal agent 20 (Compd 27) is a medication used to combat trypanosome infections, exhibiting an IC50 value of 0.75 μM against T. b. brucei.

Anti-MRSA agent 20 (Compound a4) is an antimicrobial agent targeting MRSA with a minimum inhibitory concentration (MIC) of less than 0.03125 μg/mL. It binds to the peptidyl transferase center of the ribosome, inhibiting the synthesis of MRSA toxins and bacterial division, thereby suppressing bacterial survival. Furthermore, Anti-MRSA agent 20 significantly reduces the pulmonary MRSA load and diminishes lung damage in mice infected with MRSA (ED50= 6.48 mg/kg).

Insecticidal agent 20 (Compound 17) is an insecticide that binds to AChBP. It demonstrates effective insecticidal activity against mosquito larvae (LC50: 1.57 ppm) and pupae (LC50: 4.17 ppm).

Antibacterialagent 202 (Compound 45c) is a low-cytotoxicity antibacterial agent (Bacterialinhibitor) that exhibits good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, and particularly Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) of 7.8-31.25 μM. It exerts its antibacterial effect by disrupting cell membrane integrity and is useful for research on bacterial infections.

Antibacterialagent 207 (Compound Ru1) exhibits antibacterial activity against Staphylococcus aureus with a MIC of 1 μg/mL and a low resistance frequency. It disrupts bacterial cell membranes and promotes the production of reactive oxygen species (ROS) within the bacteria.

Anticanceragent 200 (6d) is a potential anticancer agent with activity against metastasis.

Anticanceragent 201 (Compound 2f) exhibits IC50 values in the low micromolar range across various tumor cell lines. It demonstrates high in vitro cytotoxicity against CCRF-CEM cells by inducing apoptosis through the activation of caspase-3 in the mitochondrial intrinsic pathway, cleavage of PARP, and reduced expression of Bcl-2 and Bcl-XL proteins. Anticanceragent 201 can be utilized in cancer research.

Antibacterialagent 205 (Compound 10d) is an indole propene acyl-derived oxazaanthracene compound with a broad antibacterial spectrum, exhibiting a MIC of 0.25 to 0.5 μg/mL. It reduces extracellular polysaccharides and eliminates biofilms, thereby mitigating resistance. Antibacterialagent 205 exerts antibacterial effects by disrupting membrane integrity, accumulating reactive oxygen species (ROS), and inhibiting DNA replication.

Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.

Anticanceragent 203 (compound 27) is an anticancer agent that exhibits cytotoxicity and holds potential for liver cancer research.

Antibacterialagent 203 (Compound 5h) possesses both antibacterial and antifungal properties. It demonstrates effective antifungal activity against Candida albicans (C. albicans) with a MIC of 3.90 μg/mL. Additionally, Antibacterialagent 203 exhibits antibacterial activity against normal mouse fibroblasts (L929), with an IC50 of 75.96 μM.

Anticanceragent 207 (compound 10b) is an effective anticancer agent. It binds to NRAS rG4 with a KD value of 2.31 µM. It exhibits cytotoxicity and reduces NRAS protein expression, demonstrating antitumor activity.

Antibacterialagent 200 (pyridyl HH 7) is a unique hydrazine-based hydroxycoumarin (HH) characterized by potent and broad-spectrum antibacterial activity, with minimum inhibitory concentration (MIC) values ranging from 0.5-32 μg/mL against both Gram-positive and Gram-negative bacteria. It effectively inhibits Pseudomonas aeruginosa 27853 with an MIC of 0.5 μg/mL. Antibacterialagent 200 disrupts bacterial membrane integrity, leading to leakage of intracellular proteins, and interacts with bacterial DNA gyrase through non-covalent binding.

Antibacterialagent 206 (Compound 10e) is an oxanthracene compound derived from indole acryl derivatives, exhibiting a broad antibacterial spectrum with a MIC of 0.25-1 μg/mL. It reduces extracellular polysaccharides and disrupts biofilms, thus mitigating resistance. Its antibacterial effects are achieved by compromising membrane integrity, accumulating reactive oxygen species (ROS), and inhibiting DNA replication.

GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.

Anticanceragent 205 (compound 9) is an effective anticancer agent that binds to the G4-mtDNA target, inhibiting the replication, transcription, and translation of mtDNA (mitochondrial genome). It induces mitochondrial dysfunction, increases ROS production, and triggers DNA damage and cellular senescence. Anticanceragent 205 also promotes apoptosis and causes cell cycle arrest at the G0/G1 phase, showing potential for research in colorectal cancer.

Anticanceragent 202 (compound 3) acts as an anticancer agent.

GT 2016 is a H3 receptor antagonist.

Antifungal agent 20 demonstrates significant antifungal efficacy against a range of fungal pathogens including Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.