np/ova

4-Hydroxy-3-Nitrophenyl Acetate-OVAL (Ovalbumin) is a hapten-carrier protein conjugate formed by coupling 4-Hydroxy-3-Nitrophenyl Acetate (NP) to chicken ovalbumin (OVA). As a hapten, 4-Hydroxy-3-Nitrophenyl Acetate alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. 4-Hydroxy-3-Nitrophenyl Acetate-OVAL (Ovalbumin) may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.