nm-441

Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.

Tapcin is a dual inhibitor of topoisomerase I and II, with IC50 values of 203 nM and 71 nM, respectively. It effectively inhibits the proliferation of cancer cells such as A-375, HeLa, Huh7.5, U2-OS, A549, Caco-2, and HT29, with IC50 values of 441, 1.04, 40.5, 0.002, 0.006, 0.287, and 0.842 nM, respectively. Additionally, Tapcin demonstrates antitumor activity in HT29 xenograft models.

Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.

TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.

N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone toE. colicontaining the transcription factor LuxR when used at a concentration of 230 nM.2It acts as an autoinducer to activate theV. fischeriluminescence system inE. coliwhen used at concentrations ranging from 20 to 200 nM. 1.Chhabra, S.R., Stead, P., Bainton, N.J., et al.Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactoneJ. Antibiot. (Tokyo)46(3)441-454(1993) 2.Schaefer, A.L., Hanzelka, B.L., Eberhard, A., et al.Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogsJ. Bacteriol.178(10)2897-2901(1996)

GSTO1-IN-2 (Compound B-9) is a dual covalent inhibitor targeting GSTO1 and BTK with IC50 values of 441 nM and 6.2 nM, respectively.

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein, and plasmin. The substrate exhibits absorption/emission at 330/390 nm (weak fluorescence), while the end product (AMC) shows absorption/emission at 342/441 nm (strong fluorescence).

F1324 is a potent, high-affinity peptidic inhibitor of B cell lymphoma 6 (BCL6) with an IC50 of 1 nM, exhibiting a binding t1/2 value of 441 s and strong inhibitory activity against BCL6 PPI.