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Cat No. | Product Name | Synonyms | Targets |
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T5102 | TGN-020 | TGN020 | Aquaporin , PROTAC Linker |
TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain. | |||
T6581 | Methyclothiazide | Duretic,Enduron,Aquatensen | Others , Carbonic Anhydrase |
Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. | |||
T4074 | GSK-872 | GSK872,GSK'872,GSK2399872A | RIP kinase |
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). | |||
T23333 | SC-58125 | SC 58125 | COX |
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic | |||
T14968 | Cinanserin hydrochloride | SQ 10643 | Influenza Virus , 5-HT Receptor |
Cinanserin hydrochloride (SQ 10643) is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. | |||
T21412 | Ketorolac | Toradol,Sprix,Acuvail,Macril,Acular | COX |
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins. | |||
T34485 | Safotibant | LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542 | Bradykinin Receptor |
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema. | |||
T16950 | Sudoxicam | 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | COX |
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema, and antipyretic properties. | |||
T19286 | Dixyrazine | UCB 3412 | Others |
Dixyrazine (UCB 3412)has a transient antihypertensive effect, prevents cerebral edema induced by injections of ichthyosperm sulfate, and may be used in the study of neurologically related disorders. | |||
T8807 | Benzydamine | Others | |
Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. | |||
T0477 | Zileuton | Abbott 64077,A 64077 | Ferroptosis , Lipoxygenase , COX |
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca... | |||
T27143 | Delucemine Hydrochloride | NPS-1506,NPS1506,NPS 1506,Delucemine HCl,Delucemine | |
Delucemine Hydrochloride is a glutamate receptor antagonist with moderate affinity. Delucemine Hydrochloride inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells and displ... | |||
TP1168 | N-Formyl-Met-Leu-Phe-Lys | fMLFK | Others |
N-Formyl-Met-Leu-Phe-Lys (fMLFK) (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively.Chemotactic peptide (fMLFK) ... | |||
T60351 | Acetazolamide sodium | OT-302 sodium | Carbonic Anhydrase |
Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and alt... | |||
T12721 | Rho-Kinase-IN-1 | ROCK | |
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... | |||
T0755 | Carglumic Acid | Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid | Others |
Carglumic Acid (Ureidoglutaric acid) is an orphan drug used to treat hyperammonemia in patients with N-acetyl glutamate synthase absence. This rare hereditary disease results in elevated blood levels of ammonia, which ca... | |||
T36619 | Aligeron | Prostaglandin Receptor | |
Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit PGF2α-induced diarrhea in mice and PGE2-induced paw edema in... | |||
T35336 | Furosemide sodium | Frusemide Sodium,Lasix | Na-K-Cl cotransporter |
Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ... | |||
T0782 | Benzthiazide | Aquatag,Lemazide,Dihydrex | Carbonic Anhydrase |
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ... | |||
T6529 | Halobetasol propionate | Halobetasol Propionate,Ulobetasol propionate,BMY-30056,CGP-14458 | Phospholipase |
Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses acr... | |||
T37379 | Protectin D1 | ||
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phag... | |||
T33276 | Mefruside | FDA1902,FDA-1902,FDA 1902,FBA-1500,FBA1500,FBA 1500 | |
Mefruside is a diuretic indicated for the treatment of edema and hypertension. | |||
T31725 | Etozolin | GO 687,W-2900A,W2900A,GO-687,W 2900A | |
Ezozolin (Diulozin, W-2900A) is a diuretic used for the treatment of edema and hypertension. | |||
T27391 | FSBA | ||
FSBA inhibits covalently anthrax edema factor. | |||
T33725 | Norgestrienone | Planor,A-301,A301,Ogyline,A 301 | |
Nogotrienone is an anabolic steroid with fertility and contraceptive activity that has been studied as a therapeutic agent for hereditary angioneurotic edema. | |||
T33600 | Naxifylline | CVT 124,CVT-124,CVT124,BG9719 | |
Naxifylline is an A1 adenosine receptor antagonist that promotes urine volume to prevent the decline in renal function observed during diuretic therapy for the treatment of edema associated with congestive heart failure. | |||
T33294 | Mercaptomerin sodium | Diucardyn sodium,Mercaptomerine sodique,Thiomerin sodium,Letorin | |
Mercaptomerin sodium can be used to treat cardiac edema. | |||
T68926 | Indomethacin salicylate | ||
Indomethacin salicylate is an antiinflammatory drug. It has shown remarkable inhibitory effects on carrageenin edema, ultraviolet erythema and adjuvant arthritis. | |||
T24950 | VUF-10214 | VUF 10214,VUF10214 | |
VUF-10214 is an H4 receptor-ligand. VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw edema model in vivo studies in the rat reveal. | |||
T27670 | JNJ-26076713 | JNJ26076713 | |
JNJ-26076713, an orally active alpha V integrin antagonist, represents a potential therapeutic candidate for the treatment of macular edema, age-related macular degeneration, and proliferative diabetic retinopathy. | |||
T15434 | GSK2798745 | TRP/TRPV Channel | |
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated wi... | |||
T27042 | Clobenoside | Ba-43853,Ba 43853,Ba43853 | |
Clobenoside is a non-steroidal anti-inflammatory agent. Clobenoside also has an edema-protective effect while not influencing blood pressure nor heart rat and not producing any direct vasoactive effects. | |||
T38544 | Fasitibant chloride | MEN16132 free base,Fasitibant chloride | |
Fasitibant chloride (MEN16132 free base) is a powerful and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R). This compound effectively reduces joint pain and mitigates joint edema in a rat model of Carr... | |||
T34107 | Polythiazide | P2525,NSC-108161,NSC 108161,P-2525,NSC108161 | |
Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medic... | |||
T61403 | Plasma kallikrein-IN-3 | ||
Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1]. | |||
T33851 | Ozolinone | W 3282,W3282,W-3282 | |
Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hyper... | |||
T80502 | P4pal10 | ||
P4pal10, a PAR 4 antagonist, inhibits thrombin-mediated aggregation of mouse platelets in vivo and significantly diminishes Carrageenan-induced edema and granulocyte infiltration [1]. | |||
T61711 | COX-2-IN-14 | ||
COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory ac... | |||
T69990 | Ruboxistaurin mesylate monohydrate | ||
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and... | |||
T78253 | Faricimab | RG7716 | VEGFR |
Faricimab, a bispecific antibody, simultaneously targets angiopoietin-2 and vascular endothelial growth factor-A (VEGF-A), and is utilized in research on diabetic macular edema (DME) [1]. | |||
T83048 | Anti-inflammatory agent 64 | ROS Kinase | |
Anti-inflammatory agent 64 (compound 4b) exhibits antioxidant and anti-inflammatory activities, effectively inhibiting the secretion of IL-6 and TNF-α while also reducing paw edema [1] in both in vitro and in vivo studie... | |||
T36534 | SDZ 224-015 | SDZ 224015 | IL Receptor , Caspase |
SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1.SDZ 224-015 exhibits anti-COVID-19 and anti-inflammatory activity, and reduces carrageenan gum-induced paw edema in rats... | |||
T36623 | Antileukinate | ||
Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutro... | |||
T70377 | BAY 61-3606 HCl | ||
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh... | |||
T26447 | A 78773 | A78773,A-78773 | |
A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tis... | |||
T38327 | Cryogenine | ||
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the... | |||
T74422 | Sozinibercept | ||
Sozinibercept (OPT 302; VGX-300) is a soluble form of Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) that potently inhibits the activity of Vascular Endothelial Growth Factor-C and -D (VEGF-C/D), key proangiogen... | |||
T72337 | Plasma kallikrein-IN-2 | ||
Plasma kallikrein-IN-2, a potent inhibitor of plasma kallikrein (PKal) with an inhibitory concentration (IC) 50 value of 0.1 nM, is utilized in research targeting hereditary angioedema, diabetic macular edema, and diabet... | |||
T68665 | Yonkenafil | Tunodafil | |
Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, effectively reduces cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. It potentially enhances cognitive fu... | |||
T76195 | Stresscopin-related peptide (human) | ||
Stresscopin-related peptide (human), a specific ligand for the type 2 CRH receptor, effectively suppresses food intake, delays gastric emptying, and decreases heat-induced edema. It plays a crucial role in maintaining ho... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5781 | Taraxasteryl acetate | Antibacterial | |
Taraxasterol acetate has anti-inflammatory activity in bino rats against carrageenan, formaldehyde and adjuvant induced inflammations. Taraxasterol acetate also displays potential antibacterial activities. | |||
TN6706 | 3-demethylcolchicine | Reactive Oxygen Species | |
3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin. | |||
T4S0176 | Alnustone | (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one | Others |
Alnustone ((4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one) exerts significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats. | |||
T0522 | Diammonium Glycyrrhizinate | Glycyrrhizin | Dehydrogenase |
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and ... | |||
T3S0401 | Piceatannol 3'-O-glucoside | Piceatannol 3-glycoside,Quzhaqigan | Arginase , NO Synthase |
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury. | |||
T2798 | Esculetin | Aesculetin,Cichorigenin | Lipoxygenase , Akt , PI3K |
Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip... | |||
T5S1982 | Periplocin | Periplocoside | Apoptosis , Others |
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... | |||
T2978 | Mogroside V | AMPK | |
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce... | |||
TN4493 | Mannioside A | ||
Mannioside A has anti-inflammatory activity, inhibits carrageenan-induced paw edema in the rat. | |||
TN4185 | Hautriwaic acid | ||
Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by ac... | |||
T40634 | Perilla ketone | ||
Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the de... | |||
TN5151 | Tomentin | ||
Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%. | |||
T81975 | Kopsininic acid | ||
Kopsininic acid, a natural product isolated from Kopsia hainanensis, has potential applications in researching rheumatoid arthritis, pharyngitis, tonsillitis, and edema [1]. | |||
TN3447 | Arjunglucoside I | ||
Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line wi... | |||
TN1191 | 16α-Hydroxytrametenolic acid | 16 alpha-Hydroxytrametenolic acid | Others |
16 alpha-Hydroxytrametenolic acid can inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema. | |||
TN1080 | Kaji-ichigoside F1 | ||
Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo he... | |||
TN4406 | Lamiide | ||
Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation. | |||
T21893 | Luffariellolide | ||
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 ( HSF-PLA2 ) (IC 50 =5 μM). PMA-induced ear edema was effectively inhibited by luffariellolide (ED 50 =50 μg/ear) [1]. | |||
TN1623 | Escin IIB | Others , NOS | |
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice. | |||
TN1606 | (-)-Epiafzelechin | COX | |
(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-f... | |||
T73066 | Thielavin B | ||
Thielavin B, produced by Thielavia terricola, functions as an inhibitor of prostaglandin biosynthesis, specifically targeting the synthesis of prostaglandin E2 from the endoperoxide. It demonstrates significant efficacy ... | |||
T81324 | Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside | ||
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside, an orally active phenolic compound extracted from the Geranium species, exhibits anti-inflammatory properties. It shows promise for use in treatments involving edema and... | |||
TN3395 | Alpinone 3-acetate | IFNAR | |
Alpinone 3-acetate showed anti-inflammatory effects and inhibited the inflammatory response in mouse ear edema models induced by 12-O-tetradecanophenol 13-acetate. Alpinone 3-acetate is a derivative of Alpinone. Alpinone... | |||
TN4505 | Masticadienolic acid | Others | |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02956 | Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney... | |||
TMPH-02298 | Urocortin-3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. | |||
TMPY-00320 | APOA1BP Protein, Human, Recombinant (His) | Human | HEK293 |
APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites... | |||
TMPH-00217 | SVMP Protein, Bothrops leucurus, Recombinant (His & Myc) | Bothrops leucurus | E. coli |
Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also obser... | |||
TMPH-03749 | CYSLTR1 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and... | |||
TMPY-02248 | Myocilin Protein, Human, Recombinant (His) | Human | HEK293 |
Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid o... |
Cat No. | Product Name | ||
---|---|---|---|
L6710 | Anti-Inflammatory Traditional Chinese Medicine Compound Library | 1260 compounds | |
A collection of 1260 TCM monomers with anti-inflammatory activity or targeting molecular therapeutic targets in inflammation, a powerful tool for drug discovery and mechanism study; |