dcn1-ubc12

WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).

DCN1-UBC12-IN-4 (compound 5p) acts as an inhibitor of DCN1-UBC12, exhibiting an IC50 value greater than 10000 nM and possesses antitumor activity.

DCN1-UBC12-IN-1 is a potent and specific DCN1-UBC12 inhibitor with an IC50 value of 2.86 nM and anti-cardiac fibrogenic activity.

DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor with an IC50 value of 9.55 nM, targeting DCN1-UBC12 interactions and inhibiting Ang II-induced activation of cardiac fibroblasts.

DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins.

WS-383 free base is a selective and reversible DCN1-UBC12 interaction inhibitor with an IC50 of 11 nM.

WS-384 is an orally active dual inhibitor of LSD1 and DCN1-UBC12 protein-protein interactions, with IC50 values of 338.79 nM and 14.81 nM, respectively. It exhibits anticancer properties, causing cell cycle arrest, DNA damage, and inducing apoptosis (apoptosis). WS-384 can be applied in research on non-small cell lung cancer (NSCLC).

DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.

NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.