ctp

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.

CTP Synthetase-IN-1 Ammonium salt is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antimicrobial, anti-inflammatory and antitumor activity for the study of SARS-CoV-2 viral infections.

CTP518, a deuterated Atazanivir derivative, is a HIV protease inhibitor.

CTP, a cardiac targeting peptide, efficiently and specifically transduces cardiomyocytes in vitro and heart tissue in mouse models. It has potential for the targeted delivery of therapeutic peptides, proteins, and nucleic acids to the heart [1].

CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.

Cytidine 5'-diphosphate trisodium salt (CDP) catalyzes the production of Cytidine triphosphate (CTP) for DNA and RNA synthesis by transferring a phosphoryl group from ATP to cytidine monophosphate (CMP) through the action of uridine monophosphate kinase (UMPK).

Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist.

L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].

CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.

Cytarabine triphosphate (Ara-CTP), a competitive inhibitor of DNA synthesis and an active metabolite of Cytarabine, exhibits predictive potential for leukemic blasts' chemosensitivity to Cytarabine through intracellular levels.

Cytidine-5'-triphosphate sodium hydrate (Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate) is the sodium hydrate form of Cytidine-5'-triphosphate. This nucleoside triphosphate plays a crucial role in the biosynthesis of DNA, RNA, and lipids.

3′-Deoxy CTP trisodium is the sodium salt form of 3′-Deoxy CTP. This compound is a nucleotide analog known as a chain terminator. By lacking a 3′-hydroxyl group, it causes chain termination and inhibits the RNA synthesis activity of the HCV non-structural protein (NS5B) polymerase, thereby blocking viral replication. 3′-Deoxy CTP trisodium is utilized in the study of chain termination mechanisms of HCV polymerase and the development of antiviral drugs.

3′-Deoxy CTP is a nucleotide analog that functions as a potent chain terminator. By lacking a 3′-hydroxyl group, 3′-Deoxy CTP induces chain termination, thereby inhibiting the RNA synthesis activity of HCV non-structural protein (NS5B) polymerase and halting viral replication. This compound is useful for studying the chain termination mechanism of HCV polymerases and for developing antiviral drugs.

3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analogue containing a 3-azido group. It functions as a chain terminator when incorporated into nascent DNA strands by HIV reverse transcriptase, effectively inhibiting DNA synthesis due to the absence of a 3'-hydroxyl group, thereby blocking viral replication. The IC50 for WTHIV is 15.6 μM, and for AZTRHIV, it is 160.8 μM. This compound exhibits antiviral activity.

CTP inhibitor is a highly effective and specific inhibitor of the plasma membrane citrate transporter (PMCT), effectively targeting and inhibiting the transporter responsible for citrate transport. [1]

CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].

HYNIC-CTP is a conjugate of HYNIC and CTP (cardiac-targeting peptide). It acts as a chelator, allowing HYNIC to bind with the radioisotope 99mTc, resulting in the formation of 99mTc-HYNIC-CTP. This compound is specifically absorbed by the heart, facilitating cardiac imaging and thereby aiding in the research of heart diseases.

LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.

3'-NH2-CTP is a nucleotide analog modified with an amino group at the 3' position of CTP.

3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.

Cytarabine triphosphate (Ara-CTP) trisodium, an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate trisodium levels can predict the chemosensitivity of leukemic blasts to Cytarabine [1].

CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.

CTP499, a selective PDE inhibitor, and the deuterium-containing agent is an HDX analogue and a metabolite of hexantheobromine that slows the progression of type 2 diabetic nephropathy in patients with macroalbuminuria.

CTP-amiodarone, a cellular-penetrating conjugate of myocardial cell-targeting peptide and Amiodarone, exhibits anti-arrhythmic activity by blocking Na+, K+, and Ca2+ channels as well as β-adrenergic receptors.